Celastrol: An Update on Its Hepatoprotective Properties and the Linked Molecular Mechanisms.
Celastrol: An Update on Its Hepatoprotective Properties and the Linked Molecular Mechanisms.
复制标题
雷公藤红素：其保肝特性和相关分子机制的最新进展
DOI：
10.3389/fphar.2022.857956
复制
发表时间：
2022
影响因子：
5.6
通讯作者：
Jiang, Shujun
中科院分区：
文献类型：
--
作者：
Li, Mengzhen;Xie, Faren;Wang, Lu;Zhu, Guoxue;Qi, Lian-Wen;Jiang, Shujun
肝脏在葡萄糖和脂质稳态、药物代谢和胆汁合成中起重要作用。代谢紊乱和炎症协同作用导致许多肝脏疾病的发病机制，例如代谢相关性脂肪肝（MAFLD）、肝损伤和肝癌。南蛇藤酚，一种来源于雷公藤的三萜，在过去的几十年中，在代谢和炎症疾病中被广泛研究。本文就雷公藤红素在预防和治疗MAFLD、肝损伤和肝癌等肝脏疾病中的药理作用及其机制进行综述。此外，我们还讨论了雷公藤红素的药物开发的新方法和前景的重要性。虽然雷公藤红素已被认为是一种有前途的药物，对几种代谢性疾病，临床前和临床研究都非常需要加速雷公藤红素在治疗不同的肝脏疾病的临床转化。可以预见的是，雷公藤红素衍生的治疗剂在肝脏疾病领域正在发展。
The liver plays an important role in glucose and lipid homeostasis, drug metabolism, and bile synthesis. Metabolic disorder and inflammation synergistically contribute to the pathogenesis of numerous liver diseases, such as metabolic-associated fatty liver disease (MAFLD), liver injury, and liver cancer. Celastrol, a triterpene derived from Tripterygium wilfordii Hook.f., has been extensively studied in metabolic and inflammatory diseases during the last several decades. Here we comprehensively review the pharmacological activities and the underlying mechanisms of celastrol in the prevention and treatment of liver diseases including MAFLD, liver injury, and liver cancer. In addition, we also discuss the importance of novel methodologies and perspectives for the drug development of celastrol. Although celastrol has been claimed as a promising agent against several metabolic diseases, both preclinical and clinical studies are highly required to accelerate the clinical transformation of celastrol in treating different liver illness. It is foreseeable that celastrol-derived therapeutics is evolving in the field of liver ailments.
登录
查看更多内容
影响因子：
2.8
作者：
Chang, Te-Sheng;Wang, Tzi-Yuan;Wu, Jiumn-Yih
通讯作者：
Wu, Jiumn-Yih
DOI：
10.1016/j.bbadis.2019.02.002
发表时间：
2019-06-01
影响因子：
6.2
作者：
Fang, Penghua;He, Biao;Bo, Ping
通讯作者：
Bo, Ping
影响因子：
5
作者：
Chang, Wei;He, Wei;Wei, Wei
通讯作者：
Wei, Wei
雷公藤红醇抑制埃兹蛋白介导的肝癌细胞迁移
影响因子：
4.6
作者：
Du, Shihao;Song, Xiaoyu;Ding, Xia
通讯作者：
Ding, Xia
影响因子：
4.9
作者：
Chen, Xinyan;Hu, Xianxian;Zheng, Guohua
通讯作者：
Zheng, Guohua