Morphine-mimetic anti-paratypic antibodies: cross-reactive properties.
Morphine-mimetic anti-paratypic antibodies: cross-reactive properties.
复制标题
吗啡模拟抗副型抗体：交叉反应特性。
DOI：
10.1016/0006-291x(86)90458-4
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发表时间：
1986
影响因子：
3.1
通讯作者：
Pelosi,LA
中科院分区：
文献类型：
--
作者：
Glasel,JA;Pelosi,LA
多克隆，抗独特型，兔抗体已提出对四个鼠单克隆抗吗啡Fab片段。亲和纯化后的抗体制剂已显示含有可逆地抑制吗啡与抗吗啡抗体和细胞阿片受体结合的抗吗啡部分。使用这个系统的一些独特的性能，第一次的交叉反应性的抗paraffinic抗体与单克隆抗吗啡IgG已被检查，包括竞争相同的结合位点的一个经典的阿片激动剂/拮抗剂对。
Polyclonal, anti-idiotypic, rabbit antibodies have been raised against four murine monoclonal anti-morphine Fab fragments. The antibody preparations, after affinity purification, have been shown to contain an anti-paratypic fraction which reversibly inhibits morphine binding to the anti-morphine antibodies and to cellular opiate receptors. Using some of the unique properties of this system, for the first time cross-reactivities of anti-paratypic antibodies with the monoclonal anti-morphine IgGs have been examined including competition for the same binding sites by a classical opiate agonist/antagonist pair.