Follicular fluid and urinary concentrations of phthalate metabolites among infertile women and associations with in vitro fertilization parameters
Follicular fluid and urinary concentrations of phthalate metabolites among infertile women and associations with in vitro fertilization parameters
复制标题
不孕妇女卵泡液和尿液中邻苯二甲酸酯代谢物的浓度及其与体外受精参数的关联。
DOI：
10.1016/j.reprotox.2016.04.005
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发表时间：
2016-06-01
影响因子：
3.3
通讯作者：
Li, Yu-Feng
中科院分区：
文献类型：
--
作者：
Du, Yao-Yao;Fang, Yue-Li;Li, Yu-Feng
毒理学研究的证据表明，邻苯二甲酸酯可通过影响卵泡生成、卵母细胞成熟和胚胎发育而导致生育力降低，但人体数据有限。从中国武汉一家不孕症诊所采集的112名妇女的110份卵泡液（FF）和尿液样本中定量测定了8种邻苯二甲酸酯代谢物的浓度，并探讨了配对基质之间的相关性。用多变量模型评价代谢物浓度与体外受精（IVF）参数之间的关系。在>72.73%的FF样品中检测到六种代谢物。MEHP和MBP是主要代谢产物，中位水平分别为2.80和2.05 ng/mL。MEP（rs = 0.44）和MBP（rs = 0.22）的两种基质（尿液和FF）之间存在显著相关性。FF和尿代谢物浓度与任何IVF参数无关。然而，鉴于邻苯二甲酸酯暴露的普遍性，需要进一步的工作来阐明对女性生殖的潜在危害。(C)2016 Elsevier Inc. All rights reserved.
Evidence from toxicological studies has demonstrated that phthalates can lead to reduced fertility through effects on folliculogenesis, oocyte maturation and embryonic development, but human data are limited. Concentrations of eight phthalate metabolites in 110 follicular fluid (FF) and urine samples collected from 112 women attending an infertility clinic in Wuhan, China were quantified, and correlations between paired matrices were explored. Associations between metabolite concentrations and in vitro fertilization (IVF) parameters were evaluated with multivariable models. Six metabolites were detected in >72.73% of the FF samples. MEHP and MBP were the dominant metabolites with a median level of 2.80 and 2.05 ng/mL, respectively. Significant correlations between the two matrices, urine and FF, were found for MEP (rs = 0.44), and MBP (rs = 0.22). FF and urinary metabolite concentrations were not associated with any IVF parameters. However, given the prevalence of phthalates exposure, further work is needed to elucidate the potential hazard on female reproduction. (C) 2016 Elsevier Inc. All rights reserved.