Transcranial Direct Current Stimulation over Right Dorsolateral Prefrontal Cortex Enhances Error Awareness in Older Age
Transcranial Direct Current Stimulation over Right Dorsolateral Prefrontal Cortex Enhances Error Awareness in Older Age
复制标题
DOI：
10.1523/jneurosci.5308-13.2014
复制
发表时间：
2014-03-05
影响因子：
5.3
通讯作者：
O'Connell, Redmond G.
中科院分区：
文献类型：
--
作者：
Harty, Siobhan;Robertson, Ian H.;O'Connell, Redmond G.
在老年人和一系列临床人群中，在认知表现过程中检测错误的能力受到损害。本研究旨在评估经颅直流电刺激(Tdcs)对健康老年人错误意识的影响。当受试者进行错误意识的计算机化测试时，TDCS被应用于DLPFC。电流极性(阳极与阴极)和电极位置(左半球与右半球)的影响在一系列单独的单盲、Sham对照的交叉试验中进行了测试，每个试验包括24名健康的老年人(年龄65-86岁)。与右侧DLPFC相比，阳极TDC与有意识地检测到的性能错误的比例显著增加相关，这一结果在一个单独的复制实验中得到了概括。当刺激相应的对侧区域时，没有观察到这样的改善。本研究为右侧DLPFC区域在辅助错误意识中的因果作用提供了新的证据，并标志着朝着发展tDC作为一种工具的重要一步，以弥补困扰广泛人群的性能监控缺陷。
The ability to detect errors during cognitive performance is compromised in older age and in a range of clinical populations. This study was designed to assess the effects of transcranial direct current stimulation (tDCS) on error awareness in healthy older human adults. tDCS was applied over DLPFC while subjects performed a computerized test of error awareness. The influence of current polarity (anodal vs cathodal) and electrode location (left vs right hemisphere) was tested in a series of separate single-blind, Sham-controlled crossover trials, each including 24 healthy older adults (age 65-86 years). Anodal tDCS over right DLPFC was associated with a significant increase in the proportion of performance errors that were consciously detected, and this result was recapitulated in a separate replication experiment. No such improvements were observed when the homologous contralateral area was stimulated. The present study provides novel evidence for a causal role of right DLPFC regions in subserving error awareness and marks an important step toward developing tDCS as a tool for remediating the performance-monitoring deficits that afflict a broad range of populations.