Copper and immunity
Copper and immunity
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DOI：
10.1093/ajcn/67.5.1064s
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发表时间：
1998-05-01
影响因子：
7.1
通讯作者：
Percival, SS
中科院分区：
文献类型：
--
作者：
Percival, SS
免疫系统需要铜来执行几种功能，其中对直接作用机制知之甚少。动物模型和培养的细胞已被用于评估铜在免疫反应中的作用。最近的一些研究表明，白细胞介素2在铜缺乏时减少，可能是T细胞增殖减少的机制。这些结果被扩展到表明，即使在边缘缺乏，当铜的共同指标不受饮食的影响，增殖反应和白细胞介素浓度降低。在严重铜缺乏的情况下，人外周血中中性粒细胞的数量减少。它们不仅在数量上减少，而且它们产生超氧阴离子和杀死摄入的微生物的能力也在明显和边缘铜缺乏中降低。这一机制尚不清楚。中性粒细胞样HL-60细胞在分化为更成熟的细胞群时蓄积铜，这种蓄积并不通过Cu/Zn超氧化物歧化酶或细胞色素-e氧化酶活性的增加来反映。这种细胞类型中铜结合蛋白的身份可能有助于了解铜的新功能或评估铜状态。中性粒细胞，因为它们是短寿命和同质的细胞群体，被预测为评估人群营养状况的有效和有价值的工具。
The immune system requires copper to perform several functions, of which little is known about the direct mechanism of action. Animal models and cells in culture have been used to assess copper's role in the immune response. Some of the recent research showed that interleukin 2 is reduced in copper deficiency and is likely the mechanism by which T cell proliferation is reduced. These results were extended to show that even in marginal deficiency, when common indexes of copper are not affected by the diet, the proliferative response and interleukin concentrations are reduced. The number of neutrophils in human peripheral blood is reduced in cases of severe copper deficiency. Not only are they reduced in number, but their ability to generate superoxide anion and kill ingested microorganisms is also reduced in both overt and marginal copper deficiency. This mechanism is not yet understood. Neutrophil-like HL-60 cells accumulate copper as they differentiate into a more mature cell population and this accumulation is not reflected by increases in Cu/Zn superoxide dismutase or cytochrome-e oxidase activities. The identity of copper-binding proteins in this cell type may be useful in learning new functions of copper or assessing copper status. Neutrophils, because they are short-lived and homogeneous cell populations, are predicted to be an effective and valuable tool for assessing nutrient status in human populations.