Severe ovarian hyperstimulation syndrome after letrozole-gonadotropin stimulation: a case report.
Severe ovarian hyperstimulation syndrome after letrozole-gonadotropin stimulation: a case report.
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来曲唑促性腺激素刺激后严重卵巢过度刺激综合征：病例报告。
DOI：
10.1007/s10815-011-9676-8
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发表时间：
2012
影响因子：
3.1
通讯作者：
Mersereau,JenniferE
中科院分区：
文献类型：
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作者：
Kim,Jayeon;Steiner,AnneZ;Fritz,Marc;Mersereau,JenniferE
卵巢过度刺激综合征（OHSS）是由于对诱导排卵的过度反应，其特征是液体从血管内空间转移到第三空间室。中度OHSS的发生率约为3-6%，重度OHSS发生在0.1-3%的治疗周期中[1，2]。已经研究了许多因果机制，包括雌二醇（E2）、人绒毛膜促性腺激素（hCG）和血管内皮生长因子（VEGF）。E2浓度与发生OHSS的风险之间存在强烈的相关性[3]。人们对生育力保存（FP）治疗的认识和兴趣日益增加，导致许多女性寻求紧急的卵母细胞或胚胎冷冻保存。那些对雌激素敏感的癌症患者经常接受来曲唑的连续治疗，以限制暴露于通常由外源性促性腺激素刺激引起的雌激素浓度升高;来曲唑通过竞争性结合芳香酶的细胞色素P450组分来抑制雌激素的产生。组合
Ovarian hyperstimulation syndrome (OHSS) results from an exaggerated response to ovulation induction, characterized by a fluid shift from the intravascular space to third space compartments. The incidence of moderate OHSS is approximately 3–6% and severe OHSS occurs in 0.1–3% of treatment cycles [1, 2]. A number of causal mechanisms have been investigated, involving estradiol (E2), human chorionic gonadotropin (hCG), and vascular endothelial growth factor (VEGF). A strong association between E2 concentrations and risk for developing OHSS has been observed consistently [3].A growing awareness and interest in treatments aimed at fertility preservation (FP) has led many women to pursue urgent oocyte or embryo cryopreservation. Those with estrogen-sensitive cancers often receive adjunctive treatment with letrozole, in efforts to limit exposure to elevated estrogen concentrations that typically result from exogenous gonadotropin stimulation; letrozole inhibits estrogen production by binding competitively to the cytochrome P450 component of the aromatase enzyme. Combination