Unfolding neurodevelopmental disorders: the mystery of developing connections.
Unfolding neurodevelopmental disorders: the mystery of developing connections.
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11自然美国公司保留所有权利。年龄。表征这些形式的NDD的网络特性和功能网络的发展可能有助于对特发性自闭症患者的进一步分类。此外，随着这些疾病的动物模型的存在，可能有机会发现这些功能网络异常发展的细胞和分子基础。最后，根据特发性自闭症的功能连通性对这些病例进行聚类，将创建更多同质的临床人群，以进一步发现特定NDD的确切病因。功能连通性发展的确切生物学基础仍是一个悬而未决的问题。严格的解剖发育变化对于分散的大脑区域形成功能连接显然是重要的。但在神经回路中出现了额外的复杂性，因为许多功能通路没有
11 Nature America, Inc. All rights reserv ed. ages. Characterizing the network properties and development of functional networks in these forms of NDD may allow further classification of people with idiopathic forms of autism. Additionally, as animal models exist for these disorders, there may be opportunities to discover the cellular and molecular basis of the abnormal development of these functional networks. Finally, clustering those cases of idiopathic autism on the basis of their functional connectivity would create more homogeneous clinical populations to further discover the exact etiology of the specific NDD.The exact biological basis of the development of functional connectivity is still an open question. Strictly anatomical developmental changes are clearly important for dispersed brain regions to form functional connections. But there is additional complexity that arises in neural circuits, as many functional pathways do not have