Hydrocortisone induction during oligodendroglial differentiation.
Hydrocortisone induction during oligodendroglial differentiation.
复制标题
少突胶质细胞分化过程中氢化可的松诱导。
DOI：
10.1016/0304-3940(90)90499-y
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发表时间：
1990
影响因子：
2.5
通讯作者：
Miller,K
中科院分区：
文献类型：
--
作者：
Poduslo,SE;Pak,CH;Miller,K
类固醇激素对大脑的正常发育很重要。在培养物中向少突胶质细胞中加入氢化可的松增加了蛋白脂质蛋白的mRNA水平，增加了糖苷的合成，并提供了对酮体代谢酶活性的诱导。虽然蛋白脂质蛋白和β-苷是髓鞘膜的主要成分，但酮体在发育期间充当脂质合成的前体。因此，氢化可的松在少突胶质细胞的分化过程中和最初的髓鞘产生过程中是重要的。
Steroid hormones are important for the normal development of brain. The addition of hydrocortisone to oligodendroglia in culture increases the level of mRNA for proteolipid protein, increases the synthesis of cerebrosides, and provides an induction of activities for the ketone body metabolizing enzymes. While proteolipid protein and cerebrosides are major components of myelin membranes, ketone bodies serve as precursors for lipid synthesis during development. Thus, hydrocortisone is important during the differentiation of oligodendroglia and during initial myelin production.