Who begets whom? Plant cell fate determination by asymmetric cell division.
Who begets whom? Plant cell fate determination by asymmetric cell division.
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DOI：
10.1016/j.pbi.2007.11.001
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发表时间：
2008-02
影响因子：
9.5
通讯作者：
Colette A. ten Hove;R. Heidstra
中科院分区：
文献类型：
--
作者：
Colette A. ten Hove;R. Heidstra
不对称的细胞分裂产生不同命运的细胞类型。最近的研究提高了我们对拟南芥细胞不对称分裂的分子机制的理解。遗传学方法已经确定了候选的内在因素和信号成分，这些因素和信号成分介导了外部线索。WOX基因似乎是在早期胚胎不对称分裂中可能起作用的内在决定因素。涉及特定短根(SHR)-稻草人(SCR)核复合体的非典型机制涉及地面组织的不对称分裂。不对称的干细胞分裂需要外在的组织者信号，而内在的干细胞分离物的参与尚不清楚。最后，关于气孔发育的新研究已经确定了几个决定细胞命运的内在作用因素和控制不对称分裂的数量和平面的外部信号级联。
Asymmetric cell division generates cell types with different fates. Recent studies have improved our understanding of the molecular mechanisms involved in asymmetric cell division in Arabidopsis thaliana. Genetic approaches have identified candidate intrinsic factors and signaling components that mediate extrinsic cues. WOX genes appear to be putative intrinsic determinants acting in early embryonic asymmetric divisions. A non-canonical mechanism involving specific SHORT ROOT (SHR)-SCARECROW (SCR) nuclear complexes is implicated in ground tissue asymmetric divisions. Asymmetric stem cell division requires extrinsic organizer signaling, whereas the involvement of intrinsic stem cell segregants is unknown. Finally, new studies on stomatal development have identified several intrinsic acting factors that specify cell fate and an extrinsic signaling cascade that controls the number and plane of asymmetric divisions.