Brain control of movement execution onset using local field potentials in posterior parietal cortex.
Brain control of movement execution onset using local field potentials in posterior parietal cortex.
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DOI：
10.1523/jneurosci.2081-09.2009
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发表时间：
2009-11-11
期刊：
影响因子：
--
通讯作者：
Andersen RA
中科院分区：
文献类型：
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作者：
Hwang EJ;Andersen RA
运动执行起始的精确控制对于安全和自主的皮质运动假肢是必不可少的。最近的一项研究从顶叶到达区域（PRR）表明，在这个地区的局部场电位（LFP）可能是有用的解码执行时间信息，因为计划和执行状态之间的LFP频谱的显着差异。更具体地，随着状态从计划转变到执行，0-10 Hz频带中的LFP功率急剧上升，而20-40 Hz频带中的功率福尔斯下降。然而，视觉刺激的变化之前立即达到发病，提高了观察到的光谱变化反映的视觉事件，而不是达到发病的可能性。在这里，我们测试了这种可能性，并发现LFP频谱变化仍然是时间锁定的运动开始在没有视觉事件的情况下，在自定步达到。此外，我们成功地训练了猕猴受试者利用LFP频谱变化作为闭环脑控制任务中的“去”信号，在该任务中，动物只调制LFP，而不执行到达。执行开始的信号在LFP频谱的变化，而光标的目标位置是由从相同的网站记录的尖峰放电率控制。结果证实，在PRR的LFP频谱变化是一个强大的指标，运动开始，并可用于控制执行开始在皮质假体。
The precise control of movement execution onset is essential for safe and autonomous cortical motor prosthetics. A recent study from the parietal reach region (PRR) suggested that the local field potentials (LFPs) in this area might be useful for decoding execution time information because of the striking difference in the LFP spectrum between the plan and execution states. More specifically, the LFP power in the 0-10 Hz band sharply rises while the power in the 20-40 Hz band falls as the state transitions from plan to execution. However, a change of visual stimulus immediately preceded reach onset, raising the possibility that the observed spectral change reflected the visual event instead of the reach onset. Here, we tested this possibility and found that the LFP spectrum change was still time-locked to the movement onset in the absence of a visual event in self-paced reaches. Furthermore, we successfully trained the macaque subjects to utilize the LFP spectrum change as a “go” signal in a closed-loop brain-control task in which the animals only modulated the LFP and did not execute a reach. The execution onset was signaled by the change in the LFP spectrum while the target position of the cursor was controlled by the spike firing rates recorded from the same site. The results corroborate that the LFP spectrum change in PRR is a robust indicator for the movement onset and can be used for control of execution onset in a cortical prosthesis.