Self-titration by experienced e-cigarette users: blood nicotine delivery and subjective effects
Self-titration by experienced e-cigarette users: blood nicotine delivery and subjective effects
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DOI：
10.1007/s00213-016-4338-2
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发表时间：
2016-08-01
影响因子：
3.4
通讯作者：
Corcoran, Olivia
中科院分区：
文献类型：
--
作者：
Dawkins, Lynne E.;Kimber, Catherine F.;Corcoran, Olivia
自滴定在烟草文献中有很好的记载。电子烟使用者（vapers）自我滴定的程度尚不清楚。这项研究探讨了高和低尼古丁强度液体对有经验的vapers的抽吸地形、尼古丁输送和主观效果的影响。11名有经验的男性vapers在两个单独的阶段中在低（6 mg/mL）和高（24 mg/mL）尼古丁液体条件下完成了60分钟的自由吸烟。测量包括抽吸地形（抽吸次数、抽吸持续时间、消耗的液体体积）和血浆尼古丁水平、渴望、戒断症状、自我报告的命中、满意度和不良反应的变化。在低浓度条件下，尼古丁加强水平较基线的平均差异在10、30和60 min时分别为8.59（7.52）ng/mL、16.99（11.72）ng/mL和22.03（16.19）ng/mL。高浓度条件下的相应值分别为33.77（34.88）ng/mL、35.48（28.31）ng/mL和43.57（34.78）ng/mL（ps < 0.05）。在自我报告的渴望、戒断症状、满意度、命中或不良影响方面，两种情况之间没有统计学显著差异。Vapers使用尼古丁强度较低的液体进行补偿性抽吸，使其消耗量增加一倍。虽然补偿性抽吸足以减少渴望和戒断不适，但自我滴定不完全，在高条件下血浆尼古丁水平显著较高。
Self-titration is well documented in the tobacco literature. The extent to which e-cigarette users (vapers) self-titrate is unknown.This study explored the effects of high and low nicotine strength liquid on puffing topography, nicotine delivery and subjective effects in experienced vapers.Eleven experienced male vapers completed 60 min of ad libitum vaping under low (6 mg/mL) and high (24 mg/mL) nicotine liquid conditions in two separate sessions. Measurements included puffing topography (puff number, puff duration, volume of liquid consumed) and changes in plasma nicotine levels, craving, withdrawal symptoms, self-reported hit, satisfaction and adverse effects.Liquid consumption and puff number were higher and puff duration longer, in the low nicotine strength condition (all ps < 0.01). The mean difference in nicotine boost from baseline in the low condition was 8.59 (7.52) ng/mL, 16.99 (11.72) ng/mL and 22.03 (16.19) ng/mL at 10, 30 and 60 min, respectively. Corresponding values for the high condition were 33.77 (34.88) ng/mL, 35.48 (28.31) ng/mL and 43.57 (34.78) ng/mL (ps < 0.05). There were no statistically significant differences between conditions in self-reported craving, withdrawal symptoms, satisfaction, hit or adverse effects.Vapers engaged in compensatory puffing with lower nicotine strength liquid, doubling their consumption. Whilst compensatory puffing was sufficient to reduce craving and withdrawal discomfort, self-titration was incomplete with significantly higher plasma nicotine levels in the high condition.