A system for recording neural activity chronically and simultaneously from multiple cortical and subcortical regions in nonhuman primates
A system for recording neural activity chronically and simultaneously from multiple cortical and subcortical regions in nonhuman primates
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DOI：
10.1152/jn.00625.2011
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发表时间：
2012-04-01
影响因子：
2.5
通讯作者：
Graybiel, Ann M.
中科院分区：
文献类型：
--
作者：
Feingold, Joseph;Desrochers, Theresa M.;Graybiel, Ann M.
Feingold J、Desrochers TM、Fujii N、Harlan R、Tierney PL、Shimazu H、Amemori K、Graybiel AM。一种用于长期、同时记录非人类灵长类动物多个皮质和皮质下区域神经活动的系统。 J Neurophysiol 107：1979-1995，2012。首次发表于 2011 年 12 月 14 日； doi: 10.1152/jn.00625.2011.-神经科学的一个主要目标是了解神经元网络在认知和行为中的功能。最近的工作重点是植入大约 100 个不可移动电极的阵列或更少数量的可单独调节的电极，旨在针对一些皮层区域。我们开发了一种记录系统，允许长期植入多个皮质和皮质下结构的数百个电极的独立运动。我们在猕猴身上测试了这个系统，同时记录 14 个大脑区域的 127 个电极，每次记录时间长达一年。该系统的一个关键优势是，它可以用于长时间采样不同的站点组合，从单个植入生成网络活动的多个快照。这种多功能系统与微刺激和注射方法结合使用，是研究灵长类动物大脑神经网络活动的强大工具。
Feingold J, Desrochers TM, Fujii N, Harlan R, Tierney PL, Shimazu H, Amemori K, Graybiel AM. A system for recording neural activity chronically and simultaneously from multiple cortical and subcortical regions in nonhuman primates. J Neurophysiol 107: 1979-1995, 2012. First published December 14, 2011; doi: 10.1152/jn.00625.2011.-A major goal of neuroscience is to understand the functions of networks of neurons in cognition and behavior. Recent work has focused on implanting arrays of similar to 100 immovable electrodes or smaller numbers of individually adjustable electrodes, designed to target a few cortical areas. We have developed a recording system that allows the independent movement of hundreds of electrodes chronically implanted in several cortical and subcortical structures. We have tested this system in macaque monkeys, recording simultaneously from up to 127 electrodes in 14 brain regions for up to one year at a time. A key advantage of the system is that it can be used to sample different combinations of sites over prolonged periods, generating multiple snapshots of network activity from a single implant. Used in conjunction with microstimulation and injection methods, this versatile system represents a powerful tool for studying neural network activity in the primate brain.