Breath testing as potential colorectal cancer screening tool
Breath testing as potential colorectal cancer screening tool
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DOI：
10.1002/ijc.29701
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发表时间：
2016-01-01
影响因子：
6.4
通讯作者：
Haick, Hossam
中科院分区：
文献类型：
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作者：
Amal, Haitham;Leja, Marcis;Haick, Hossam
尽管结直肠癌(CRC)筛查已被世界上许多国家纳入有组织的计划，但仍有更好的筛查工具的存在。在这项研究中，收集了65例结直肠癌患者、22例晚期或非晚期腺瘤患者和122例对照患者的418份呼吸样本。所有患者，包括对照组，都接受了结肠镜检查。用两种不同的技术对样品进行了分析。第一种技术依赖于气相色谱-质谱法(GC-MS)来鉴定和定量挥发性有机化合物(VOCs)。使用T检验来确定显著的VOCs(p值
Although colorectal cancer (CRC) screening is included in organized programs of many countries worldwide, there is still a place for better screening tools. In this study, 418 breath samples were collected from 65 patients with CRC, 22 with advanced or nonadvanced adenomas, and 122 control cases. All patients, including the controls, had undergone colonoscopy. The samples were analysed with two different techniques. The first technique relied on gas chromatography coupled with mass spectrometry (GC-MS) for identification and quantification of volatile organic compounds (VOCs). The T-test was used to identify significant VOCs (p values