Effects of remote cutaneous pain on trigeminal laser-evoked potentials in migraine patients
Effects of remote cutaneous pain on trigeminal laser-evoked potentials in migraine patients
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DOI：
10.1007/s10194-007-0385-8
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发表时间：
2007-06-01
影响因子：
7.4
通讯作者：
Livrea, Paolo
中科院分区：
文献类型：
--
作者：
de Tommaso, Marina;Difruscolo, Olimpia;Livrea, Paolo
本研究旨在评估偏头痛患者与非偏头痛健康对照者在远程应用辣椒素期间CO2激光热刺激后的热痛阈值和诱发电位（激光诱发电位，LEPs）。12名无先兆偏头痛门诊患者与10名健康对照者进行比较。采用6个头皮电极，分别在基础状态下、3%辣椒素涂抹左手背期间和去除辣椒素后刺激右手背和右眶上区，记录lep的变化。在正常受试者中，相对于辣椒素使用前和使用后，远程辣椒素刺激手和面部获得的激光疼痛和N2-P2顶点复合体显著减少，而在偏头痛患者中，远程疼痛刺激对lep和激光疼痛没有显著改变。在偏头痛中，有缺陷的脑干抑制控制可能与对面部疼痛的注意力集中的认知因素共存，对第二次疼痛的注意力分散不太敏感。
The present study aimed to evaluate heat pain thresholds and evoked potentials following CO2 laser thermal stimulation (laser-evoked potentials, LEPs), during remote application of capsaicin, in migraine patients vs. non-migraine healthy controls. Twelve outpatients suffering from migraine without aura were compared with 10 healthy controls. The LEPs were recorded by 6 scalp electrodes, stimulating the dorsum of the right hand and the right supraorbital zone in basal condition, during the application of 3% capsaicin on the dorsum of the left hand and after capsaicin removal. In normal subjects, the laser pain and the N2-P2 vertex complex obtained by the hand and face stimulation were significantly reduced during remote capsaicin application, with respect to pre- and post-capsaicin conditions, while in migraine LEPs and laser pain were not significantly modified during remote painful stimulation. In migraine a defective brain-stem inhibiting control may coexist with cognitive factors of focalised attention to facial pain, less sensitive to distraction by a second pain.