Positive Relationship Between Plasma Leptin Level and Hypertension
Positive Relationship Between Plasma Leptin Level and Hypertension
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DOI：
10.1161/hypertensionaha.109.148213
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发表时间：
2010-10
期刊：
影响因子：
8.3
通讯作者：
A. Shankar;Jie Xiao
中科院分区：
文献类型：
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作者：
A. Shankar;Jie Xiao
瘦素是一种脂肪组织来源的激素，与高血压发生发展中的代谢、炎症和止血因子有关。动物研究表明，较高的瘦素水平可能会激活交感神经系统，导致血压（BP）升高。然而，很少有研究探讨瘦素和人类高血压之间的关联。此外，还不清楚妇女和男子之间是否存在这种联系。因此，我们在美国成年人的代表性样本中研究了血浆瘦素水平与高血压之间的关系。我们检查了第三次全国健康和营养检查调查参与者>20岁（n=5599; 54.7%女性）。血浆瘦素水平分为四分位数（女性：21.70 fg/L;男性：7.12 fg/L）。高血压定义为使用降压药物或收缩压≥140 mm Hg和/或舒张压≥90 mm Hg。我们发现，在调整了年龄、性别、种族/民族、教育、吸烟、饮酒、体重指数、糖尿病、血清胆固醇和C反应蛋白后，较高的血浆瘦素水平与高血压呈正相关。与瘦素第1四分位数（参考）相比，与第4四分位数相关的高血压的比值比（95%CI）为1.89（1.24至2.09;趋势P =0.0036）。亚组分析检查瘦素和高血压之间的关系，性别和体重指数类别也显示出一致的正相关。总之，在美国成年人的代表性样本中，女性和男性的血浆瘦素水平较高与高血压相关。
Leptin is an adipose tissue-derived hormone shown to be related to metabolic, inflammatory, and hemostatic factors involved in hypertension development. Animal studies suggest that higher leptin levels may activate the sympathetic nervous system and cause elevations in blood pressure (BP). However, few studies have examined the association between leptin and hypertension in humans. Also it is not clear whether this association is present among women as well as men. Therefore, we examined the association between plasma leptin levels and hypertension in a representative sample of US adults. We examined the third National Health and Nutrition Examination Survey participants >20 years of age (n=5599; 54.7% women). Plasma leptin levels were categorized into quartiles (women: 21.70 fg/L; men: 7.12 fg/L). Hypertension was defined as BP-reducing medication use or having systolic BP ≥140 mm Hg and/or diastolic BP ≥90 mm Hg. We found that higher plasma leptin levels were positively associated with hypertension after adjusting for age, sex, race/ethnicity, education, smoking, alcohol intake, body mass index, diabetes mellitus, serum cholesterol, and C-reactive protein. Compared with quartile 1 of leptin (referent), the odds ratio (95% CI) of hypertension associated with quartile 4 was 1.89 (1.24 to 2.09; P for trend=0.0036). Subgroup analyses examining the relation between leptin and hypertension by sex and body mass index categories also showed a consistent positive association. In conclusion, higher plasma leptin levels are associated with hypertension both among women as well as men in a representative sample of US adults.