Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting
Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting
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DOI：
10.1016/j.clnu.2016.03.011
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发表时间：
2016-12-01
影响因子：
6.3
通讯作者：
Varady, Krista A.
中科院分区：
文献类型：
--
作者：
Hoddy, Kristin K.;Gibbons, Catherine;Varady, Krista A.
背景和目标：隔日禁食（ADF；“禁食日”摄入 25% 能量，与“进食日”随意摄入能量交替）对减肥有效。 ADF 是否能够通过增强饮食依从性和减轻体重的方式调节饥饿感、饱腹感和肠道肽，目前仍不清楚。因此，本研究检查了 ADF 对餐后食欲等级和肠肽的影响。方法：肥胖受试者 (n = 59) 参加了为期 8 周的 ADF 方案，其中在禁食日提供食物。结果：8 周节食后体重下降 (P < 0.0001) 3.9 +/- 0.6 kg。还观察到脂肪量（-2.2 +/- 0.2 kg）、去脂量（-1.4 +/- 0.2 kg）、内脏脂肪量（-0.1 +/- 0.1 kg）和静息代谢率（RMR；-104 +/- 28 kcaliday）的减少（P < 0.05）。空腹瘦素和胰岛素下降（P < 0.05），而 AUC 胃饥饿素水平增加（P < 0.05）。尽管存在这些代谢变化，但到研究结束时主观饥饿感并未增加。此外，饱腹感和 PYY 增加（P < 0.05）。无脂体重和 RMR 在任何时间点都与饥饿或生长素释放肽无关。结论：这些发现表明，饥饿补偿性增加与饱腹感增加的结合可能有助于 8 周 ADF 方案的减肥效果。 (C) 2016 Elsevier Ltd 和欧洲临床营养与代谢学会。版权所有。
Background & aims: Alternate day fasting (ADF; 25% energy intake "fast day", alternated with an ad libitum intake "feed day") is effective for weight loss. Whether or not ADF modulates hunger, fullness and gut peptides in a way that enhances dietary compliance and weight loss, remains unknown. Accordingly, this study examined the effect of ADF on postprandial appetite ratings and gut peptides.Methods: Obese subjects (n = 59) participated in an 8-week ADF protocol where food was provided on the fast day.Results: Body weight decreased (P < 0.0001) by 3.9 +/- 0.6 kg after 8 weeks of diet. Reductions (P < 0.05) in fat mass (-2.2 +/- 0.2 kg), fat free mass (-1.4 +/- 0.2 kg), visceral fat mass (-0.1 +/- 0.1 kg), and resting, metabolic rate (RMR; -104 +/- 28 kcaliday) were also observed. Fasting leptin and insulin decreased (P < 0.05), while AUC ghrelin levels increased (P < 0.05). Despite these metabolic changes, there was no increase in subjective hunger by the end of the study. Furthermore, fullness and PYY increased (P < 0.05). Fat free mass and RMR were not related to hunger or ghrelin at any time point.Conclusion: These findings suggest that the absence of a compensatory increase in hunger in conjunction with an increase in sensations of fullness may contribute to the weight loss efficacy of an 8-week ADF regimen. (C) 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.