The association of repeated measurements of prenatal exposure to triclosan with fetal and early-childhood growth.
The association of repeated measurements of prenatal exposure to triclosan with fetal and early-childhood growth.
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DOI：
10.1016/j.envint.2018.07.022
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发表时间：
2018-07
影响因子：
11.8
通讯作者：
Chuansha Wu;Jiufeng Li;W. Xia;Yuan-yuan Li;Bin Zhang;Aifen Zhou;Jie Hu;Chunhui Li;Hongzhi Zhao-Hongz
中科院分区：
文献类型：
--
作者：
Chuansha Wu;Jiufeng Li;W. Xia;Yuan-yuan Li;Bin Zhang;Aifen Zhou;Jie Hu;Chunhui Li;Hongzhi Zhao-Hongz
BackgroundTriclosan (TCS) is known to possess endocrine disrupting properties and metabolize rapidly in the human body. Human data concerning repeated measurements of TCS throughout pregnancy in relation to fetal and childhood growth are sparse.ObjectivesWe investigated the associations between multiple measurements of maternal urinary concentrations of TCS during pregnancy and fetal and early-childhood growth.MethodsThe study population included 850 mother-infant pairs who participated in a prenatal cohort established between 2014 and 2015 in Wuhan. Prenatal TCS exposure was measured in a complete series of urine samples collected at the first, second and third trimesters. General linear models and generalized estimating equation models were applied to evaluate the associations of the averaged maternal urinary concentrations of TCS over trimesters and trimester-specific urinary TCS with thez-scores of estimated fetal weight, head circumference, abdominal circumference, and femur length at 16, 24, and 31 gestational weeks, weight and length at birth, and weight and height at 0.5, 1, and 2 years of age.ResultsIn overall infants, we did not observe any significant association of the averaged maternal urinary concentrations of TCS over trimesters with ultrasound parameters and size at birth. However, a positive association of borderline statistical significance was found between averaged prenatal TCS exposure and the third-trimester estimated fetal weightz-score in girls in sex-stratified analyses (β = 0.054, 95% CI: −0.005, 0.113,p= 0.07). Moreover, averaged prenatal TCS exposure was positively associated with 2 year-old weightz-score among total infants (β = 0.046, 95% CI: 0.005, 0.087). After stratifying by sex, the same association was observed in girls with more prominent estimation (β = 0.062, 95% CI: 0.000, 0.124), whereas the association weakened and became not significant in boys (β = 0.033, 95% CI: −0.024, 0.089). TCS exposure at 1st and 2nd-trimester were positively associated with weightz-score at 2 years, in both overall and female infants.ConclusionsPrenatal exposure to triclosan was associated with elevated third-trimester estimated fetal weight and 2 year-old weightz-score in girls, and the early and middle stage of pregnancy may be the windows of vulnerability. Apart from these findings, we did not find strong evidence for prenatal triclosan exposure in relation to fetal and early-childhood growth.
