Fructose ingestion acutely elevates blood pressure in healthy young humans
Fructose ingestion acutely elevates blood pressure in healthy young humans
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DOI：
10.1152/ajpregu.00680.2007
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发表时间：
2008-03-01
影响因子：
2.8
通讯作者：
Montani, Jean-Pierre
中科院分区：
文献类型：
--
作者：
Brown, Clive M.;Dulloo, Abdul G.;Montani, Jean-Pierre
过量消费果糖，特别是以软饮料的形式，越来越被认为是一个公共卫生问题。然而，摄入果糖的急性心血管反应在人类中还没有得到很好的研究。在这项随机交叉研究中，我们比较了15名健康志愿者(年龄21-33岁)在摄入含有葡萄糖或果糖的水和饮料后的心血管自主神经调节。每种饮品的总容量为500ml，糖含量为60g，每次饮酒前30min和每次饮品后2 h记录心率、动脉压和心输出量。能源消耗是按分钟计算的。摄入果糖饮料可以显著增加血压、心率和心输出量，但不会增加总外周阻力。摄入葡萄糖后，心输出量的增加明显大于果糖，但血压没有变化，总外周阻力也随之降低。摄入葡萄糖和果糖，但不摄入水，显著增加血压变异性，降低心脏迷走神经压力感受器反射敏感性。摄入葡萄糖和果糖后，能量消耗增加了类似的量，但果糖引起的呼吸商的增加明显更大。这些结果表明，摄取葡萄糖和果糖饮料具有特定的血液动力学反应。特别是，摄入果糖会引起血压升高，这可能是通过增加心输出量而没有代偿性外周血管扩张来调节的。
Overconsumption of fructose, particularly in the form of soft drinks, is increasingly recognized as a public health concern. The acute cardiovascular responses to ingesting fructose have not, however, been well-studied in humans. In this randomized crossover study, we compared cardiovascular autonomic regulation after ingesting water and drinks containing either glucose or fructose in 15 healthy volunteers (aged 21-33 yr). The total volume of each drink was 500 ml, and the sugar content 60 g. For 30 min before and 2 h after each drink, we recorded beat-to-beat heart rate, arterial blood pressure, and cardiac output. Energy expenditure was determined on a minute-by-minute basis. Ingesting the fructose drink significantly increased blood pressure, heart rate, and cardiac output but not total peripheral resistance. Glucose ingestion resulted in a significantly greater increase in cardiac output than fructose but no change in blood pressure and a concomitant decrease in total peripheral resistance. Ingesting glucose and fructose, but not water, significantly increased blood pressure variability and decreased cardiovagal baroreflex sensitivity. Energy expenditure increased by a similar amount after glucose and fructose ingestion, but fructose elicited a significantly greater increase in respiratory quotient. These results show that ingestion of glucose and fructose drinks is characterized by specific hemodynamic responses. In particular, fructose ingestion elicits an increase in blood pressure that is probably mediated by an increase in cardiac output without compensatory peripheral vasodilatation.