Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology.
Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology.
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DOI：
10.1038/s44220-023-00057-5
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发表时间：
2023-05
期刊：
影响因子：
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通讯作者：
Fornito, Alex
中科院分区：
文献类型：
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作者：
Tiego, Jeggan;Martin, Elizabeth A;DeYoung, Colin G;Hagan, Kelsey;Cooper, Samuel E;Pasion, Rita;Satchell, Liam;Shackman, Alexander J;Bellgrove, Mark A;Fornito, Alex
在过去的几十年里，我们测量人类生物学各方面的能力得到了迅速发展，但这些技术对精神病理学的生物学相关性的洞察速度远远落后。进展缓慢的部分原因是文献中许多发现的敏感性、特异性和可重复性较差，而这些结果又被归因于效应规模小、样本量小和统计能力不足。通常提出的解决方案是专注于大的、联盟大小的样本。然而，非常明显的是，增加样本量将产生有限的影响，除非解决一个更根本的问题：测量目标行为表型的精确度。在这里，我们讨论挑战，概述几个前进的方向，并提供实际例子来展示关键问题和潜在的解决方案。一种精确的表型方法可以增强生物学和精神病理学之间的关联的发现和可复制性。
Our capacity to measure diverse aspects of human biology has developed rapidly in the past decades, but the rate at which these techniques have generated insights into the biological correlates of psychopathology has lagged far behind. The slow progress is partly due to the poor sensitivity, specificity and replicability of many findings in the literature, which have in turn been attributed to small effect sizes, small sample sizes and inadequate statistical power. A commonly proposed solution is to focus on large, consortia-sized samples. Yet it is abundantly clear that increasing sample sizes will have a limited impact unless a more fundamental issue is addressed: the precision with which target behavioral phenotypes are measured. Here, we discuss challenges, outline several ways forward and provide worked examples to demonstrate key problems and potential solutions. A precision phenotyping approach can enhance the discovery and replicability of associations between biology and psychopathology.