Optimization of a Model Corrected Blood Input Function from Dynamic FDG-PET Images of Small Animal Heart In Vivo.
Optimization of a Model Corrected Blood Input Function from Dynamic FDG-PET Images of Small Animal Heart In Vivo.
复制标题
通过体内小动物心脏的动态FDG-PET图像的模型校正血液输入功能的优化。
DOI：
10.1109/tns.2013.2269032
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发表时间：
2013-10
影响因子：
1.8
通讯作者：
Kundu BK
中科院分区：
文献类型：
--
作者：
Zhong M;Kundu BK
由于小鼠心脏的体积较小，且PET扫描仪的空间分辨率有限，因此在活体小鼠心脏的动态正电子发射断层扫描(PET)的定量评估是具有挑战性的。在这里，我们优化了一个间隔模型，该模型可以同时校正血池和心肌的溢出效应和部分体积效应，计算动力学参数，并从经过衰减校正的有序子集期望最大化-最大后验概率(OSEM-MAP)心脏和呼吸门控18F-FDG PET图像中生成模型校正的血液输入函数(MCBIF)，而无需任何侵入性血液采样。采集了一只小鼠的动脉血样本，以表明所提出的方法的可行性。为了建立统计学意义，在SP从组织到血液的污染最严重的两个后期时间点采集了n=6只小鼠的静脉血样本。我们观察到，PV和SP系数的正确界限和初始猜测准确地模拟了小鼠血液中示踪剂的洗入和洗出动态。残留图显示，血样与MCBIF之间的平均差异约为1.7%。心肌FDG内流常数的下行率Ki(0.15±0.03min−1)与动脉血Ki(P=0.716)比较，差异有统计学意义。总之，所提出的方法不仅是定量的，而且是可重复性的。
Quantitative evaluation of dynamic Positron Emission Tomography (PET) of mouse heart in vivo is challenging due to the small size of the heart and limited intrinsic spatial resolution of the PET scanner. Here, we optimized a compartment model which can simultaneously correct for spill over and partial volume effects for both blood pool and the myocardium, compute kinetic rate parameters and generate model corrected blood input function (MCBIF) from ordered subset expectation maximization – maximum a posteriori (OSEM-MAP) cardiac and respiratory gated 18F-FDG PET images of mouse heart with attenuation correction in vivo, without any invasive blood sampling. Arterial blood samples were collected from a single mouse to indicate the feasibility of the proposed method. In order to establish statistical significance, venous blood samples from n=6 mice were obtained at 2 late time points, when SP contamination from the tissue to the blood is maximum. We observed that correct bounds and initial guesses for the PV and SP coefficients accurately model the wash-in and wash-out dynamics of the tracer from mouse blood. The residual plot indicated an average difference of about 1.7% between the blood samples and MCBIF. The downstream rate of myocardial FDG influx constant, Ki (0.15±0.03 min−1), compared well with Ki obtained from arterial blood samples (P=0.716). In conclusion, the proposed methodology is not only quantitative but also reproducible.