Thioredoxin interacting protein (TXNIP) rs7212 polymorphism is associated with arterial stiffness in the Brazilian general population
Thioredoxin interacting protein (TXNIP) rs7212 polymorphism is associated with arterial stiffness in the Brazilian general population
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DOI：
10.1038/jhh.2011.102
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发表时间：
2012-05-01
影响因子：
2.7
通讯作者：
Pereira, A. C.
中科院分区：
文献类型：
--
作者：
Alvim, R. O.;Santos, P. C. J. L.;Pereira, A. C.
硫氧还蛋白相互作用蛋白作为生物力学和氧化应激的生物传感器，在心血管内稳态的几个重要过程中发挥着关键作用。然而，遗传变异在调节动脉僵硬中的作用尚不清楚。在这种情况下，本研究评估了TXNIP rs7212基因多态与动脉僵硬的关系。在总样本和糖尿病组中，携带CG+GG基因的个体的PWV值高于CC基因携带者(分别为10.0vs 9.8ms(-1)，P=0.03；12.3vs 11.2ms(-1)，P=0.01)。我们的发现表明，G等位基因可能与巴西普通人群中动脉僵硬的增加有关，并提示与糖尿病可能存在相互作用。
Thioredoxin interacting protein plays a pivotal role in several important processes of cardiovascular homeostasis by functioning as a biological sensor for biomechanical and oxidative stress. However, the effects of genetic variants in the modulation of arterial stiffness are unknown. In this scenario, the present study evaluated the relationship between the TXNIP rs7212 polymorphism and arterial stiffness. In the overall sample and in the diabetic group, individuals carrying CG + GG genotypes had higher PWV values compared with CC genotype group ( 10.0 vs 9.8 ms(-1), P = 0.03; 12.3 vs 11.2 ms(-1), P = 0.01; respectively). Our findings indicated that the G allele may contribute to increased arterial stiffness in the Brazilian general population and suggest a possible interaction with diabetes.