The major components of human energy balance during chronic beta-adrenergic blockade.
The major components of human energy balance during chronic beta-adrenergic blockade.
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DOI：
10.1097/00008483-200007000-00006
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发表时间：
2000-07-01
期刊：
影响因子：
--
通讯作者：
Caldwell, M
中科院分区：
文献类型：
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作者：
Lamont, L S;Brown, T;Caldwell, M
目得：作者比较了能量平衡的主要组成部分-膳食食物摄入量，静息代谢率和身体能量消耗-在接受β受体阻滞剂的患者和健康controls.METHODS：作者招募了受试者谁正在接受β受体阻滞剂（n = 22）从当地医院和诊所。根据年龄、体重和性别，将22名健康对照与每位患者相匹配。采用间接量热法测定静息代谢率。三天的饮食摄入量和体力活动assessments.RESULTS：有没有组间差异的热量摄入或自我报告的体力活动模式。然而，β受体阻滞剂组的静息代谢率较低（β受体阻滞剂组= 1，541 +/- 464千卡/天;对照组= 1，817 +/- 426千卡/天; P < 0.05）。结论：β受体阻滞剂可导致静息代谢率降低。因此，β受体阻滞的个体应该增加体力活动，减少饮食摄入，或两者兼而有之，以保持每日能量平衡，防止伴随代谢率降低的体重增加。
PURPOSE: The authors compare the major components of energy balance--dietary food intake, resting metabolic rate, and physical energy expenditure--in patients receiving beta-blocking medications and healthy controls.METHODS: The authors recruited subjects who were receiving beta-blocking agents (n = 22) from local hospitals and clinics. Twenty-two healthy controls were matched to each patient based on age, weight, and gender. Resting metabolic rates were determined using indirect calorimetry. Three-day dietary intakes and physical activity assessments were analyzed.RESULTS: There were no between-group differences in calories ingested or self-reported physical activity patterns. However, resting metabolic rates were lower in the beta-blocked subjects (beta-blocked = 1,541 +/- 464 kcals/day; controls = 1,817 +/- 426 kcals/day; P < 0.05).CONCLUSIONS: beta-adrenergic blockade causes a reduction in resting metabolic rate. Therefore, beta-blocked individuals should increase physical activity, decrease dietary intake, or both to maintain daily energy balance and prevent weight gain that accompanies a reduction in metabolic rate.