Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice.
Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice.
复制标题
纤溶酶缺乏不会改变小鼠内源性鼠淀粉样蛋白水平。
DOI：
10.1016/j.neulet.2004.07.011
复制
发表时间：
2004
影响因子：
2.5
通讯作者：
Estus,Steven
中科院分区：
文献类型：
--
作者：
Tucker,HMichael;Simpson,James;Kihiko-Ehmann,Muthoni;Younkin,LindaH;McGillis,JosephP;Younkin,StevenG;Degen,JayL;Estus,Steven
Deposition of amyloid beta (Aβ) into extracellular plaques is a pathologic characteristic of Alzheimer’s disease. Plasmin, neprilysin, endothelin-converting enzyme and insulin-degrading enzyme (IDE) have each been implicated in Aβ degradation; data supporting the role of the latter three enzymes have included increased levels of endogenous murine Aβ in mice genetically deficient for the respective enzyme. In this study, we sought to determine if plasminogen deficiency increases endogenous Aβ. We report that plasminogen deficiency did not result in an Aβ increase in the brain or in the plasma of adult mice. Hence, although plasmin is potentially important in the degradation of Aβ aggregates, we interpret these data as suggesting that plasmin does not regulate steady-state Aβ levels in non-pathologic conditions.
