The role of development and adrenal steroids in the regulation of the mineralocorticoid receptor messenger RNA.
The role of development and adrenal steroids in the regulation of the mineralocorticoid receptor messenger RNA.
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发育和肾上腺类固醇在盐皮质激素受体信使 RNA 调节中的作用。
DOI：
10.1055/s-2007-1003269
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Perlman,AJ
中科院分区：
文献类型：
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作者：
Kalinyak,JE;Bradshaw,JG;Perlman,AJ
本实验研究了盐皮质激素受体（MR）mRNA在大鼠脑和肾中的个体发育、肾上腺反馈调节和区域分布。在肾脏中，成人的MR mRNA水平仅为新生儿浓度的25-30%。肾上腺切除术导致脑MR mRNA总量增加35%，肾MR mRNA水平增加94%。MR mRNA在脑内的区域分布的检查显示，海马具有最高水平，并且mRNA丰度在肾上腺切除术后增加。地塞米松的管理，以完整的动物导致MR mRNA在新生大鼠的肾脏，但不是在大脑中的显着减少。这些数据表明，有发育变化的MR基因表达在肾脏和肾上腺皮质类固醇激素可以调节MR基因表达在大脑和肾脏。
The ontogeny, adrenal-feedback regulation and regional distribution of the mineralocorticoid receptor (MR) mRNA were examined in the rat brain and kidney. In the kidney, MR mRNA levels in the adult were only 25-30% of the neonatal concentration. Adrenalectomy caused a 35% increase in total brain MR mRNA and a 94% increase in kidney MR mRNA levels. Examination of the regional distribution of the MR mRNA within the brain revealed that the hippocampus had the highest levels, and the mRNA abundance increased after adrenalectomy. The administration of dexamethasone to intact animals resulted in a significant reduction of MR mRNA in the kidney of neonatal rats but not in the brain. These data indicate that there are developmental changes in MR gene expression in kidney and that adrenal steroids can modulate MR gene expression in both the brain and kidney.