Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)aspartamide]-based polymers
Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)aspartamide]-based polymers
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聚[(N-2-羟乙基)天冬酰胺]基聚合物的可控合成及后修饰研究
DOI：
10.1039/c6py02230h
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发表时间：
2017
影响因子：
4.6
通讯作者：
Lichen Yin
中科院分区：
文献类型：
--
作者：
Shixian Lv;Yuchen Wu;Jingqi Dang;Zhaohui Tang;Ziyuan Song;Sheng Ma;Xiao Wang;Xuesi Chen;Jianjun Cheng;Lichen Yin
聚[(N-2-羟乙基)-天冬氨酰胺](PHEA)材料的合成不理想，后处理反应活性低，阻碍了PHEA材料的生产。在此，我们报道了PHEA基聚合物的控制合成，解开了PHEA中的氢键，开发了通过提高温度来提高PHEA反应活性的有效方法，并进一步证明了PHEA基两亲性化合物所需的水溶解性和冻干稳定性。这项研究将为设计实用和功能化的多肽生物材料提供见解。
The production of poly-[(N-2-hydroxyethyl)-aspartamide] (PHEA)-based materials is hampered by the unsatisfactory synthesis and low reactivity in terms of post-modification. Herein, we report the controlled synthesis of PHEA-based polymers, unraveled the hydrogen bonding in PHEA, developed effective approaches to enhance the reactivity of PHEA by improving the temperature, and further demonstrated the desired aqueous solubility as well as the lyophilization stability of PHEA-based amphiphiles. This study will provide insights into the design of useful and functionalized polypeptide-based biomaterials.