The relationship of structural alterations to cognitive deficits in schizophrenia: A voxel-based morphometry study
The relationship of structural alterations to cognitive deficits in schizophrenia: A voxel-based morphometry study
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DOI：
10.1016/j.biopsych.2005.04.036
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发表时间：
2005-09-15
影响因子：
10.6
通讯作者：
Sharma, T
中科院分区：
文献类型：
--
作者：
Antonova, E;Kumari, V;Sharma, T
背景资料：感兴趣区域研究已经确定了精神分裂症中的一些结构-认知关联，并揭示了这一人群中结构-认知关系的改变。我们研究了使用基于体素的形态测量学确定的脑结构改变，45名精神分裂症患者与43名健康对照者的认知缺陷，并检验了结构-精神分裂症患者认知关系改变。患者的全脑、灰质和白色物质体积较小。区域性改变是左半球特异性的，包括：额下回、舌回和前上级颞回的灰质减少;后叶和枕叶的白色物质减少;壳核和楔前叶的灰质增加。较小的全脑和灰质体积与较低的病前智商（IQ）和较差的表现在IQ依赖的认知措施住院患者和对照组在类似的程度。较大的楔前叶与患者较好的即时言语记忆相关，而对照组的言语和非言语记忆与额下回体积呈正相关。较小的枕叶白色物质体积与较慢的信息处理速度，在患者中，但不是在对照subjects.Conclusions：区域体积的改变与特定的认知缺陷精神分裂症。一些结构认知关系将该人群与健康对照受试者区分开来。
Background: Region of interest studies have identified a number of structure-cognition associations in schizophrenia and revealed alterations in structure-cognition relationship in this population.Methods: We examined the relationship of structural brain alterations, identified using voxel-based morphometry, to cognitive deficits in 45 schizophrenia patients relative to 43 healthy control subjects and tested the hypothesis that structure-cognition relationship is altered in schizophrenia.Results. Patients had smaller total brain, gray matter, and white matter volumes. Regional alterations were left-hemisphere specific, including: gray matter reduction of inferior frontal, lingual, and anterior superior temporal gyri; white matter reduction of posterior and occipital lobes; and gray matter increase of the putamen and the precuneus. Smaller whole brain and gray matter volumes were associated with lower premorbid intelligence quotient (IQ) and poorer performance on IQ-dependent cognitive measures inpatients and to a similar extent in control subjects. Larger precuneus was associated with better immediate verbal memory inpatients, whereas verbal and nonverbal memory were positively associated with inferior frontal gyrus volume in control subjects. Smaller occipital white matter volume was associated with slower information processing speed, in patients but not in control subjects.Conclusions: Regional volume alterations are associated with specific cognitive defects in schizophrenia. Some structure cognition relationships differentiate this population from healthy control subjects.