A Novel Water-Soluble Heptaplatin Analogue with Improved Antitumor Activity and Reduced Toxicity
A Novel Water-Soluble Heptaplatin Analogue with Improved Antitumor Activity and Reduced Toxicity
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一种新型水溶性七铂类似物，具有提高的抗肿瘤活性和降低的毒性
DOI：
10.1021/ic200436u
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发表时间：
2011-06-20
影响因子：
4.6
通讯作者：
Lou, Liguang
中科院分区：
文献类型：
--
作者：
Liu, Weiping;Chen, Xizhu;Lou, Liguang
合成了一种新的水溶性七铂类似物cis-[（4 R，5 R）-4，5-双（氨甲基）-2-异丙基-1，3-二氧杂环戊烷]（3-羟基-1，1-环丁烷二羧酸）铂（II），并对其生物活性进行了评价。该配合物比其母体药物heptaplatin具有更高的活性和更低的毒性，显示出巨大的开发潜力。
A novel water-soluble heptaplatin analogue, cis-[(4R,5R)-4,5-bis-(aminomethyl)-2-isopropyl-1,3-dioxo-lane](3-hydroxy-1,1-cyclobutanedicarboxylato)platinum-(II), has been synthesized and biologically evaluated. The complex shows more activity and less toxicity than its parent drug heptaplatin, exhibiting the great potential for further development.