Lack of cellular and humoral immunological responses to oats in adults with coeliac disease
Lack of cellular and humoral immunological responses to oats in adults with coeliac disease
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作者：
Janatuinen, EK;Kemppainen, TA;Mäki, M
最近的研究表明，燕麦不会伤害患有乳糜泻的成年人的肠绒毛。由于燕麦的免疫学效应尚未详细研究，因此决定将无麸质饮食（包括燕麦）与常规无麸质饮食（包括燕麦）的免疫学反应进行比较。设计-一项随机对照干预研究，为期6-12个月。受试者-40名新诊断腹腔疾病的成人和52名缓解期腹腔疾病的成人进行了检查。Intervention-the effects of a gluten free diet including oats and a conventional gluten free diet before and after the intervention. Results-The rate of disappearance of gluten and reticulin antibodies does not different between the diet groups in patients with newly diagnosed coeliac disease. Intervention-the effects of a gluten free diet including oats and a conventional gluten free diet before and after the intervention.Results-The rate of disappearance of gluten and reticulin antibodies does not different between the diet groups in patients with newly diagnosed coeliac disease.燕麦对缓解患者的麦醇溶蛋白或网硬蛋白抗体水平也没有影响。IELS的数量下降类似的饮食新诊断的患者，无论在缓解或不燕麦的患者IELS的数量没有增加。结论这些结果加强了这样的观点，即腹腔疾病的成年患者可以消耗适量的燕麦没有不良的免疫影响。
Objective-Recent research suggests that oats do not harm intestinal villi in adults with coeliac disease. As the immunological effects of oats have not been examined in detail, it was decided to compare the immunological responses of a gluten free diet including oats with those of a conventional gluten free diet.Design-A randomised controlled intervention study over 6-12 months.Subjects-Forty adults with newly diagnosed coeliac disease and 52 with coeliac disease in remission were examined. Intervention-The effects of a gluten free diet including oats and a conventional gluten free diet were compared.Main outcome measures-Serum levels of gliadin and reticulin antibodies as well as numbers of intraepithelial lymphocytes (IELs) in intestinal mucosa were examined before and after the intervention.Results-The rate of disappearance of gliadin and reticulin antibodies did not differ between the diet groups in patients with newly diagnosed coeliac disease. Oats also had no effect on gliadin or reticulin antibody levels in the patients with remission. The number of IELs decreased similarly regardless of the diet of newly diagnosed patients, and no increase in the number of IELs was found in the patients in remission with or without oats.Conclusions-These results strengthen the view that adult patients with coeliac disease can consume moderate amounts of oats without adverse immunological effects.