Platelet mitochondrial function: from regulation of thrombosis to biomarker of disease.
Platelet mitochondrial function: from regulation of thrombosis to biomarker of disease.
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DOI：
10.1042/bst20120327
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发表时间：
2013-02
影响因子：
3.9
通讯作者：
Sergey I Zharikov;S. Shiva
中科院分区：
文献类型：
--
作者：
Sergey I Zharikov;S. Shiva
循环中的血小板内含有少量功能齐全的线粒体。越来越多的证据表明，这些线粒体不仅通过产生能量，而且还通过氧化还原信号和启动细胞凋亡来调节血小板的血栓前功能。除了对止血的调节外，由于与其他代谢活跃的组织相比，血小板更容易获得，所以传统上也被用来识别和研究人类疾病中的线粒体功能障碍。在这篇文章中，我们简要概述了目前对血小板线粒体功能的了解，并综述了如何利用血小板线粒体来研究人类疾病中的线粒体功能。
Circulating blood platelets contain small numbers of fully functional mitochondria. Accumulating evidence demonstrates that these mitochondria regulate the pro-thrombotic function of platelets through not only energy generation, but also redox signalling and the initiation of apoptosis. Beyond its regulation of haemostasis, platelet mitochondrial function has also traditionally been used to identify and study mitochondrial dysfunction in human disease, owing to the easy accessibility of platelets compared with other metabolically active tissues. In the present article, we provide a brief overview of what is currently known about the function of mitochondria in platelets and review how platelet mitochondria have been used to study mitochondrial function in human disease.