Temperature-controlled assembly and release from polymer vesicles of poly(ethylene oxide)-block-poly(N-isopropylacrylamide)
Temperature-controlled assembly and release from polymer vesicles of poly(ethylene oxide)-block-poly(N-isopropylacrylamide)
复制标题
DOI：
10.1002/adma.200601019
复制
发表时间：
2006-11-03
影响因子：
29.4
通讯作者：
Yang, Shu
中科院分区：
文献类型：
--
作者：
Qin, Shuhui;Geng, Yan;Yang, Shu
聚（环氧乙烷）-嵌段-聚（N-异丙基丙烯酰胺）的窄分散性温敏嵌段共聚物在32摄氏度以上的温度下自组装成囊泡。囊泡将疏水性荧光染料整合到其膜中，并封装亲水性抗癌药物阿霉素。如图所示，在低于32 ℃的温度下，通过囊泡的崩解进行染料的温度控制释放。
Narrow-dispersity thermoresponsive block copolymers of poly(ethylene oxide)-block-poly(N-isopropylacrylamide) self-assemble into vesicles at temperatures above 32 degrees C. The vesicles integrate a hydrophobic fluorescent dye into their membranes and encapsulate the hydrophilic anticancer drug doxorubicin. Temperature-controlled release of the dye through disintegration of the vesicles takes place at temperatures below 32 degrees C, as shown in the figure.