Chronic fatigue syndrome: Identification of distinct subgroups on the basis of allergy and psychologic variables
Chronic fatigue syndrome: Identification of distinct subgroups on the basis of allergy and psychologic variables
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DOI：
10.1016/s0091-6749(98)70090-9
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发表时间：
1998-08-01
影响因子：
14.2
通讯作者：
Jones, JF
中科院分区：
文献类型：
--
作者：
Borish, L;Schmaling, K;Jones, JF
Background: We investigated a role for allergic inflammation and psychologic parameters in the development of chronic fatigue syndrome (CFS),Methods: The design was a comparison between subjects with CFS and age- and sex-matched control cohorts. Studies were performed on CFS subjects (n =18) and control cohorts consisting of normal subjects (n = 11), allergic subjects (n = 14), and individuals with primary depression (n = 12), We quantified cytokines at baseline as cell-associated immunoreactive peptides and as transcripts evaluated by means of semiquantitative RNA-based polymerase chain reactions. Psychologic evaluations included administration of the Diagnostic Interview Schedule, the Structured Clinical Interview, and the Symptom Checklist 90-Revised.Results: Increases in tumor necrosis factor (TNF)-alpha were identified in individual subjects with CFS (50.1 +/- 14.4 pg TNF-alpha per 10(7) peripheral blood mononuclear cells [PBMCs]; mean +/- SEM) and allergic subjects (41.6 +/- 7.6) in comparison with normal subjects (13.1 +/- 8.8) (P
