Plants and animals share functionally common bacterial virulence factors
Plants and animals share functionally common bacterial virulence factors
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DOI：
10.1073/pnas.97.16.8815
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发表时间：
2000-08-01
影响因子：
11.1
通讯作者：
Tompkins, RG
中科院分区：
文献类型：
--
作者：
Rahme, LG;Ausubel, FM;Tompkins, RG
通过利用铜绿假单胞菌感染各种脊椎动物和非脊椎动物宿主的能力，我们开发了使用植物和线虫作为哺乳动物模型的替代物的模型系统，以帮助阐明铜绿假单胞菌发病机制的分子基础。我们的研究揭示了铜绿假单胞菌用于感染不同进化起源宿主的毒力机制具有显著的保守性。
By exploiting the ability of Pseudomonas aeruginosa to infect a variety of vertebrate and nonvertebrate hosts, we have developed model systems that use plants and nematodes as adjuncts to mammalian models to help elucidate the molecular basis of P. aeruginosa pathogenesis. Our studies reveal a remarkable degree of conservation in the virulence mechanisms used by P. aeruginosa to infect hosts of divergent evolutionary origins.