Effect of Roux-en-Y Gastric Bypass Surgery on the Sex Steroids and Quality of Life in Obese Men
Effect of Roux-en-Y Gastric Bypass Surgery on the Sex Steroids and Quality of Life in Obese Men
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DOI：
10.1210/jc.2008-1598
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发表时间：
2009-04-01
影响因子：
5.8
通讯作者：
Meikle, A. Wayne
中科院分区：
文献类型：
--
作者：
Hammoud, Ahmad;Gibson, Mark;Meikle, A. Wayne
内容：减肥手术对肥胖男性生殖功能的影响尚未完全阐明。目的：本研究的目的是确定Roux-En-Y胃旁路手术对肥胖男性生殖激素和性功能的影响。设计和设置：在临床研究中心对该队列进行了2年的随访。患者：64名严重肥胖的男性（22名接受了胃旁路手术，42名对照）参与了这项研究。干预措施：测量人体测量学[体重，体重指数（BMI）和体脂百分比]和生殖激素。性生活质量的评估使用的影响体重对生活质量-Lite questionnaire.Main Outcome Measure（s）：生殖激素和性生活质量进行了measured.Results：平均年龄为48.9 +/- 1.2 yr.基线时，平均体重为333.0 +/- 7.1 lb，BMI为46.2 +/- 0.9 kg/m2，总睾酮为339.9 +/- 21.32 ng/dl。BMI与雌二醇呈正相关，与总睾酮和游离睾酮呈负相关。对性生活质量不满意的指数与肥胖的测量呈正相关。性功能障碍和性欲低下与游离睾酮和总睾酮呈负相关（r =-0.273，P = 0.038; r =-0.267，P = 0.042）。2年后，胃旁路手术组的BMI显著降低，（-16.6 +/- 1.2对比-0.46 +/- 0.51 kg/m2）和雌二醇（-8.1 +/- 2.4 vs. 1.6 +/- 1.4 pg/ml），总睾酮增加（310.8 +/- 47.6 vs. 14.2 +/- 15.3 ng/dl）和游离睾酮（45.2 +/- 5.1 vs.-0.4 +/- 3.0 pg/ml）。结论：肥胖男性性生活质量下降和性激素水平的改变与肥胖程度有关，胃旁路手术后两者均得到改善。（临床内分泌代谢杂志94：1329-1332，2009）
Context: The effect of bariatric surgery on the reproductive function of obese men is not entirely elucidated.Objective: The aim of the study was to define the effect of Roux-En-Y gastric bypass surgery on the reproductive hormones and sexual function in obese men.Design and Setting: The cohort was followed for 2 yr at a clinical research center.Patients: Sixty-four severely obese men (22 who had gastric bypass surgery and 42 controls) participated in the study.Intervention(s): Anthropometrics [weight, body mass index (BMI), and percentage body fat] and reproductive hormones were measured. The sexual quality of life was assessed using the Impact of Weight on the Quality Of Life-Lite questionnaire.Main Outcome Measure(s): Reproductive hormones and sexual quality of life were measured.Results: The mean age was 48.9 +/- 1.2 yr. At baseline, mean weight was 333.0 +/- 7.1 lb, BMI was 46.2 +/- 0.9 kg/m(2), and total testosterone was 339.9 +/- 21.32 ng/dl. BMI correlated positively with estradiol and negatively with total and free testosterone. Indices of dissatisfaction with sexual quality of life correlated positively with measures of obesity. Difficult sexual performance and low sexual desire correlated negatively with free and total testosterone (r = -0.273, P = 0.038; and r = -0.267, P = 0.042, respectively). After 2 yr, the gastric bypass surgery group had a significant decrease in BMI (-16.6 +/- 1.2 vs. -0.46 +/- 0.51 kg/m(2)) and estradiol (-8.1 +/- 2.4 vs. 1.6 +/- 1.4 pg/ml) and had an increase in total testosterone (310.8 +/- 47.6 vs. 14.2 +/- 15.3 ng/dl) and free testosterone (45.2 +/- 5.1 vs. -0.4 +/- 3.0 pg/ml). Sexual quality of life was improved after gastric bypass surgery.Conclusion: Hormonal alterations and diminished sexual quality of life among obese men are related to degree of obesity, and both are improved after gastric bypass surgery. (J Clin Endocrinol Metab 94: 1329-1332, 2009)