The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, 99mTc) radiopharmaceuticals
The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, 99mTc) radiopharmaceuticals
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DOI：
10.1039/c1cc15451f
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Benny, Paul D.
中科院分区：
文献类型：
--
作者：
Ganguly, Tanushree;Kasten, Benjamin B.;Benny, Paul D.
Facile reactivity of hydrazides and aldehydes was explored as potential coupling partners for incorporation into M(CO)(3) (M = Re, Tc-99m) based radiopharmaceuticals. Both 'click, then chelate' and 'prelabel, then click' synthetic routes produced identical products in high yields and lacked metal-hydrazide/-hydrazone interactions, highlighting the potential of this click strategy.
