Toward Systems-Level Metabolic Analysis in Endocrine Disorders and Cancer.
Toward Systems-Level Metabolic Analysis in Endocrine Disorders and Cancer.
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DOI：
10.3803/enm.2023.1814
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发表时间：
2023-12
期刊：
影响因子：
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通讯作者：
Park JO
中科院分区：
文献类型：
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作者：
Lakhani A;Kang DH;Kang YE;Park JO
新陈代谢是一个动态的生化反应网络，在不断变化的营养、环境和身体活动因素中支持系统体内平衡。循环系统促进器官之间的代谢物交换，而内分泌系统通过激素释放微调新陈代谢。肥胖、糖尿病和库欣综合征等内分泌疾病会破坏这种平衡，导致全身炎症和全球健康负担。它们伴随着从分子相互作用到单个器官到整个身体的多个层面的代谢变化。了解代谢通量与内分泌失调的关系有助于阐明潜在的失调。癌症越来越被认为是一种全身性疾病，因为它不仅影响局部肿瘤的细胞，而且影响整个身体，尤其是转移时。在肿瘤发生过程中，肿瘤微环境中的癌症特异性突变和营养可用性会重新编程细胞代谢，以满足增加的能量和生物合成需求。癌症恶病质会导致肌肉、脂肪组织和肝脏等其他器官的代谢变化。本综述探讨了健康和疾病中内分泌系统和系统级代谢之间的相互作用。我们重点关注肥胖、糖尿病、库欣综合征和癌症等疾病中的代谢通量。代谢组学、通量组学和系统生物学的最新进展有望为动态代谢提供新的见解，提供潜在的生物标志物、治疗靶点和个性化医疗。
Metabolism is a dynamic network of biochemical reactions that support systemic homeostasis amidst changing nutritional, environmental, and physical activity factors. The circulatory system facilitates metabolite exchange among organs, while the endocrine system finely tunes metabolism through hormone release. Endocrine disorders like obesity, diabetes, and Cushing’s syndrome disrupt this balance, contributing to systemic inflammation and global health burdens. They accompany metabolic changes on multiple levels from molecular interactions to individual organs to the whole body. Understanding how metabolic fluxes relate to endocrine disorders illuminates the underlying dysregulation. Cancer is increasingly considered a systemic disorder because it not only affects cells in localized tumors but also the whole body, especially in metastasis. In tumorigenesis, cancer-specific mutations and nutrient availability in the tumor microenvironment reprogram cellular metabolism to meet increased energy and biosynthesis needs. Cancer cachexia results in metabolic changes to other organs like muscle, adipose tissue, and liver. This review explores the interplay between the endocrine system and systems-level metabolism in health and disease. We highlight metabolic fluxes in conditions like obesity, diabetes, Cushing’s syndrome, and cancers. Recent advances in metabolomics, fluxomics, and systems biology promise new insights into dynamic metabolism, offering potential biomarkers, therapeutic targets, and personalized medicine.
DOI：
10.1002/path.5997
发表时间：
2022-11
期刊：
The Journal of pathology
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