The effects of overfeeding and propensity to weight gain on the neuronal responses to visual food cues
The effects of overfeeding and propensity to weight gain on the neuronal responses to visual food cues
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DOI：
10.1016/j.physbeh.2009.03.019
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发表时间：
2009-07-14
影响因子：
2.9
通讯作者：
Cornier, Marc-Andre
中科院分区：
文献类型：
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作者：
Cornier, Marc-Andre
在美国和全世界，肥胖是一个严重且日益严重的公共健康问题。肥胖日益流行的病理生理过程尚未明确定义，但可能涉及有利于正能量平衡的环境因素与遗传易感个体的体重调节系统之间的错误相互作用。在目前的环境中，具有苗条遗传倾向的人可能比那些有肥胖倾向的人能够更快、更准确地感觉到过量的能量摄入并做出反应。能量摄入的调节以及对能量平衡变化的潜在适应是一个复杂的过程，稳态和非稳态信号之间的相互作用可能是关键。我们观察到，瘦(抗肥胖)的人很快就能感觉到正能量平衡的变化，不仅是食欲指标的变化，还有对能量摄入调节至关重要的大脑区域的变化。这与肥胖减少(肥胖倾向)的人形成对比，他们似乎没有适当地感觉到正能量平衡的变化，这表明肥胖抵抗和肥胖倾向的人对正能量平衡有不同的敏感性。我们还发现了外部食物提示和大脑区域激活之间重要相互作用的证据，这些区域在能量平衡的动态平衡调节中起重要作用。这些发现强调了环境视觉线索的重要作用，并表明外部视觉感觉输入、能量平衡状态和大脑中调节能量摄入的重要区域之间的相互作用存在重要的表型差异。(C)2009 Elsevier Inc.保留所有权利。
Obesity is a serious and growing public health problem in the United States and the world. The pathophysiological processes that underlie the increasing prevalence of obesity have not been clearly defined but likely involve faulty interactions between environmental factors, which favor positive energy balance, and weight regulatory systems in genetically susceptible individuals. Individuals who are genetically predisposed to thinness in the current environment may be able to sense and respond to excess energy intake more rapidly and accurately than those predisposed to obesity. The regulation of energy intake and therefore the potential adaptation to changes in energy balance is a complex process with interactions between homeostatic and non-homeostatic signals likely being critical. We have observed that thin (obese-resistant) individuals quickly sense changes in positive energy balance with not only changes in measures of appetite but also in brain regions important for the regulation of energy intake. This is in contrast to reduced-obese (obese-prone) individuals who do not appear to appropriately sense the changes in positive energy balance, suggesting that there is a differential sensitivity to positive energy balance between obese-resistant and obese-prone individuals. We have also found evidence for important interactions between external food cues and activation of brain regions important in the homeostatic regulation of energy balance. These findings emphasize the important role of environmental visual cues and suggest that there are important phenotypic differences in the interactions between external visual sensory inputs, energy balance status, and brain regions important in the regulation of energy intake. (C) 2009 Elsevier Inc. All rights reserved.