Role of the SLIT-ROBO signaling pathway in renal pathophysiology and various renal diseases.
Role of the SLIT-ROBO signaling pathway in renal pathophysiology and various renal diseases.
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DOI：
10.3389/fphys.2023.1226341
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发表时间：
2023
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
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SLIT配体及其受体ROBO最初被认为在中枢神经系统发育中的轴突导向作用。近年来，随着研究的深入，SLIT-ROBO信号通路的作用逐渐从轴突排斥扩展到细胞迁移、肿瘤发展、血管生成和骨代谢。作为一种分泌蛋白，SLIT调节肾脏的各种病理生理过程，如促炎反应和纤维化进展。许多研究表明，SLIT-ROBO广泛参与肾脏发育的各个方面以及结构和功能的维持。SLIT-ROBO信号通路在不同类型的肾脏疾病中也起着重要作用。本文综述了SLIT-ROBO通路在各种肾脏病理生理和肾脏疾病中的研究进展，并提出了该领域进一步研究的新方向。
SLIT ligand and its receptor ROBO were initially recognized for their role in axon guidance in central nervous system development. In recent years, as research has advanced, the role of the SLIT-ROBO signaling pathway has gradually expanded from axonal repulsion to cell migration, tumor development, angiogenesis, and bone metabolism. As a secreted protein, SLIT regulates various pathophysiological processes in the kidney, such as proinflammatory responses and fibrosis progression. Many studies have shown that SLIT-ROBO is extensively involved in various aspects of kidney development and maintenance of structure and function. The SLIT-ROBO signaling pathway also plays an important role in different types of kidney disease. This article reviews the advances in the study of the SLIT-ROBO pathway in various renal pathophysiological and kidney disorders and proposes new directions for further research in this field.
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DOI：
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发表时间：
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影响因子：
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