Association of polymorphisms in the estrogen receptor α gene with body fat distribution
Association of polymorphisms in the estrogen receptor α gene with body fat distribution
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DOI：
10.1038/sj.ijo.0802378
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发表时间：
2003-09-01
影响因子：
4.9
通讯作者：
Shimokata, H
中科院分区：
文献类型：
--
作者：
Okura, T;Koda, M;Shimokata, H
目的：研究雌激素受体（ER）α基因的多态性是否与体脂分布相关。设计：ER α基因第一内含子的两个单核苷酸多态性（T-->C（PvuII）和A-->G（XbaI））的横断面流行病学研究。受试者：共2238名社区居住的日本中老年人群（年龄：40-79岁）。测量：ER α基因型结果：GG基因型女性的脂肪量（FM）和腰围与年龄呈负相关（r分别为-0.630和-0.504）。AA基因型腰围与年龄呈正相关（r=0.231）。因此，对于具有AG或GG基因型的中年妇女（40-59岁），体重指数（BMI）、%FM、FM、腰围、臀围和腰臀比（WHR）均大于具有AA基因型的中年妇女。特别是，与AA基因型相比，GG基因型的FM和腰围分别大20%和9%。另外，与AA基因型相比，GG基因型老年女性的FM和腰围分别小18%和6%。在男性中，A-->G多态性之间没有发现影响。在男性和女性中，除了老年男性（60-79岁）的BMI外，TT、TC和CC基因型之间的其他变量均无差异。结论：ER α基因多态性与男性体脂分布无相关性。对于女性，A->G多态性，特别是GG基因型，可能有助于中年个体的上半身肥胖的发展，但可能有助于减少老年个体的全身和腹部脂肪组织。
Objective: To examine whether polymorphisms of the estrogen receptor (ER) alpha gene are associated with body fat distribution.Design: Cross-sectional, epidemiological study of two single-nucleotide polymorphisms, a T-->C (PvuII) and an A-->G ( XbaI), in the first intron of the ERalpha gene.Subjects: A total of 2238 community-dwelling middle-aged and elderly Japanese population (age: 40-79 y).Measurements: The ERalpha genotypes (by automated fluorescent allele-specific DNA primer assay system), anthropometric variables, fat mass (FM) and percentage FM (%FM) (by dual-energy X-ray absorptiometry).Results: FM and waist were inversely associated with age (r=-0.630 and -0.504, respectively) in women with the GG genotype. On the other hand, waist circumference of the AA genotype was positively correlated with age (r=0.231). Thus, for middle-aged women (40-59 y) with the AG or GG genotype body mass index (BMI), %FM, FM, waist, hip and waist-to-hip ratio (WHR) were larger than those with the AA genotype. In particular, FM and waist were greater by 20% and 9%, respectively, for the GG genotype, compared to the AA genotype. Alternatively, FM and waist were smaller by 18% and 6%, respectively, in older women with the GG genotype, compared to the AA genotype. No effect was found among the A-->G polymorphisms for men. For both genders, no difference was found in any variables among the TT, TC and CC genotypes with the exception of BMI of older men (60-79 y).Conclusion: No association was found between the ERalpha gene polymorphisms and body fat distribution in men. For women, the A-->G polymorphism, in particular the GG genotype, may contribute to the development of upper-body obesity in middle-aged individuals, but may serve to decrease the whole-body and abdominal fat tissue of older individuals.