Semen quality of workers occupationally exposed to hydrocarbons
Semen quality of workers occupationally exposed to hydrocarbons
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DOI：
10.1016/s0015-0282(99)00515-4
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发表时间：
2000-02-01
影响因子：
6.7
通讯作者：
Pedrón-Nuevo, N
中科院分区：
文献类型：
--
作者：
De Celis, R;Feria-Velasco, A;Pedrón-Nuevo, N
目的：确定男性因职业接触碳氢化合物是否对其精液质量产生不利影响。设计：比较研究。背景：墨西哥城的橡胶工业。患者：48 名接触碳氢化合物 2-24 年的工人和 42 名未接触碳氢化合物的工人。干预措施：无。主要结果指标：通过对工厂所有区域的连续空气监测来确定环境碳氢化合物浓度。精液样本分析按照世界卫生组织标准进行。结果：碳氢化合物浓度如下：乙苯，220.7-234 mg/m(3)；苯，31.9-47.8 mg/m(3)；甲苯，189.7-212.5 mg/m(3)；和二甲苯，47-56.4 mg/m3。未暴露组中射精具有正常特征的受试者数量（76%）多于暴露组（17%）。与未接触过的工人相比，接触过接触过的工人的精液中发现了更多的异常特征，包括粘度、液化能力、精子数量、精子活力和正常形态精子比例的改变。一些异常特征与接触碳氢化合物的年数相关。结论：与未接触碳氢化合物的工人相比，接触碳氢化合物的工人精液异常率增加，证明了碳氢化合物暴露对生精过程的损害。该信息可能有助于未来分析与接触高浓度碳氢化合物相关的生殖风险。 （Feril Steril(R) 2000；73:221-8。(C) 2000 年，美国生殖医学会）。
Objective: To determine whether occupational exposure of men to hydrocarbons has adverse effects on the quality of their semen.Design: Comparative study.Setting: The rubber industry in Mexico City.Patient(s): Forty-eight workers who were exposed to hydrocarbons for 2-24 years and 42 unexposed workers.Intervention(s): None.Main Outcome Measure(s): Environmental hydrocarbon concentrations were determined by continuous air monitoring in all areas of the factory. Analyses of semen samples were performed in accordance with World Health Organization criteria.Result(s): Hydrocarbon concentrations were as follows: ethylbenzene, 220.7-234 mg/m(3); benzene, 31.9-47.8 mg/m(3); toluene, 189.7-212.5 mg/m(3); and xylene, 47-56.4 mg/m3. The number of subjects with ejaculates that had normal characteristics was greater in the unexposed group (76%) than in the exposed group (17%). More abnormal characteristics were found in the semen of exposed workers than unexposed workers, including alterations in viscosity, liquefaction capacity, sperm count, sperm motility, and the proportion of sperm with normal morphology. Some abnormal characteristics correlated with the number of years of exposure to the hydrocarbons.Conclusion(s): Damage to the spermatogenic process resulting from hydrocarbon exposure was demonstrated by an increased rate of abnormalities in the semen of exposed workers compared with unexposed workers. This information may be useful for conducting future analyses of reproductive risks related to exposure to high concentrations of hydrocarbons. (Feril Steril(R) 2000;73:221-8. (C) 2000 by American Society for Reproductive Medicine).