Dual roles of yes-associated protein (YAP) in colorectal cancer.
Dual roles of yes-associated protein (YAP) in colorectal cancer.
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yes 相关蛋白 (YAP) 在结直肠癌中的双重作用
DOI：
10.18632/oncotarget.20155
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发表时间：
2017-09-26
期刊：
影响因子：
--
通讯作者：
Ma J
中科院分区：
文献类型：
--
作者：
Ou C;Sun Z;Li S;Li G;Li X;Ma J
yes相关蛋白（YAP）是新出现的肿瘤抑制通路Hippo通路的下游效应分子。YAP是一种转录共激活因子，在包括结直肠癌（CRC）在内的多种癌症中错误表达。越来越多的研究表明，核YAP的高表达与肿瘤进展和生存率降低有关。核YAP可与其他转录因子相互作用，促进癌细胞增殖、凋亡、转移和维持干性。因此，YAP有可能成为结直肠癌的肿瘤生物标志物或治疗靶点。然而，最近的一些研究支持了YAP作为肿瘤抑制因子的矛盾作用，表明YAP抑制CRC的肿瘤发生，参与促进细胞凋亡，抑制肠道干细胞的维持和炎症活性。在这些研究中，YAP的高表达与CRC中较差的生存率高度相关。在这篇综述中，我们将全面总结和分析这些矛盾的报道，并讨论YAP在结直肠癌进展的不同状态中的致癌和抑瘤功能。进一步探讨YAP双重功能的作用机制，对结直肠癌的预防、早期诊断和治疗具有重要意义。
Yes-associated protein (YAP) is a downstream effector molecule of a newly emerging tumour suppressor pathway called the Hippo pathway. YAP is a transcriptional co-activator and mis-expressed in various cancers, including colorectal cancer (CRC). Accumulating studies show that the high expression of nuclear YAP is linked with tumour progression and decreased survival. Nuclear YAP can interact with other transcription factors to promote cancer cell proliferation, apoptosis, metastasis and maintenance of stemness. Therefore, YAP has the potential to be a tumour biomarker or therapeutic target for CRC. However, recently, a number of studies have supported a contradictory role for YAP as a tumour suppressor, demonstrating inhibition of the tumorigenesis of CRC, involvement in promoting cell apoptosis, and inhibiting the maintenance of intestinal stem cells and inflammatory activity. In these studies, high expression of YAP was highly correlated with worse survival in CRC. In this review, we will comprehensively summarize and analyse these paradoxical reports, and discuss both the oncogenic and tumour suppressor functions of YAP in the differential status of CRC progression. Further investigation into the mechanisms responsible for the dual function of YAP will be of great value in the prevention, early diagnosis, and therapy of CRC.
影响因子：
3.1
作者：
Kim H
通讯作者：
Kim H