Effects of hyaluronic acid on peripheral nerve scarring and regeneration in rats
Effects of hyaluronic acid on peripheral nerve scarring and regeneration in rats
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DOI：
10.1002/micr.10209
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发表时间：
2003-01-01
期刊：
影响因子：
2.1
通讯作者：
Özgenel, GY
中科院分区：
文献类型：
--
作者：
Özgenel, GY
本实验研究的目的是在成年大鼠模型中研究局部应用透明质酸对周围神经瘢痕形成和再生的影响。将48只大鼠右侧坐骨神经切断后立即修复，随机分为两组。施加透明质酸的神经构成实验组，施加盐水的神经构成对照组。在第4周和第12周，通过肉眼和组织学评价神经周围瘢痕形成。用透明质酸处理的神经显示出神经周围瘢痕厚度的显著减少（P < 0.05，Student’s t检验）。在12周时进行组织形态学神经分析、电生理学研究、肌肉质量评估和系列功能行走轨迹分析以评价周围神经再生。结果显示，透明质酸处理的神经传导速度更好，轴突纤维直径增加，功能恢复更快（P < 0.05，Student's t检验）。总之，透明质酸似乎是有效地防止周围神经瘢痕形成，从而增强周围神经再生。(C)2003 Wiley-Liss，Inc.
The purpose of this experimental study was to investigate the effects of topical applications of hyaluronic acid on peripheral nerve scarring and regeneration in an adult rat model. After the right sciatic nerves of 48 rats were transected and immediately repaired, nerves were randomly divided into two groups. Nerves to which were applied hyaluronic acid comprised the experimental group, and nerves to which were applied saline comprised the control group. Perineural scarring was evaluated at 4 and 12 weeks macroscopically and histologically. Nerves treated with hyaluronic acid demonstrated significant reduction in perineural scar thickness (P < 0.05, Student's t-test). Histomorphologic nerve analysis, electrophysiologic studies, muscle mass evaluation, and serial functional walking-track analysis were performed for evaluation of peripheral nerve regeneration at 12 weeks. The results showed better conduction velocities, increased axon-fiber diameter, and faster functional recovery in hyaluronic acid-treated nerves (P < 0.05, Student's t-test). In conclusion, hyaluronic acid appears to be effective in preventing perineural scar formation, resulting in enhancement of peripheral nerve regeneration. (C) 2003 Wiley-Liss, Inc.