Insulin resistance syndrome in 8-year-old Indian children - Small at birth, big at 8 years, or both?
Insulin resistance syndrome in 8-year-old Indian children - Small at birth, big at 8 years, or both?
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DOI：
10.2337/diabetes.48.12.2422
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发表时间：
1999-12-01
期刊：
影响因子：
7.7
通讯作者：
Joglekar, C
中科院分区：
文献类型：
--
作者：
Bavdekar, A;Yajnik, CS;Joglekar, C
我们研究了477名8岁的印度儿童，以确定出生体重与心血管危险因素之间的关系，包括胰岛素抵抗综合征（IRS）变量和血浆总胆固醇和LDL胆固醇浓度。所有的危险因素都与目前的体重密切相关。在校正了目前的体重、年龄和性别后，低出生体重与高收缩压相关（P = 0.008），空腹血浆胰岛素和32-33分裂胰岛素原浓度（P = 0.08和0.02），葡萄糖后30分钟的葡萄糖和胰岛素浓度（P = 0.06和0.04），肩胛下/三头肌皮褶比（P = 0.003），血浆总胆固醇和LDL胆固醇浓度（P = 0.002和0.001）。低出生体重与计算的胰岛素抵抗增加相关（稳态模型评估[HOMA]，P = 0.03），但与β细胞功能的HOMA指数无关。IRS变量、总胆固醇和LDL胆固醇水平最高的是出生体重低但8岁时脂肪量高的儿童。8岁时身高较高预示着空腹血浆胰岛素浓度、胰岛素抵抗以及血浆总胆固醇和低密度脂蛋白胆固醇浓度较高。胰岛素抵抗最严重的儿童是那些父母身材矮小但自己却长得很高的儿童。虽然我们的研究结果与身高的关系尚不清楚，但改善胎儿生长和控制儿童肥胖的干预措施可能是预防印度心血管疾病和IRS的重要因素。
We have studied 477 8-year-old Indian children to define the relationship between birth weight and cardiovascular risk factors, including insulin resistance syndrome (IRS) variables and plasma total and LDL cholesterol concentrations. All risk factors were strongly related to current weight. After adjustment for current weight, age, and sex, lower birth weight was associated with higher systolic blood pressure (P = 0.008), fasting plasma insulin and 32-33 split proinsulin concentrations (P = 0.08 and 0.02), glucose and insulin concentrations 30 min postglucose (P = 0.06 and 0.04), subscapular/triceps skinfold ratio (P = 0.003), and plasma total and LDL cholesterol concentrations (P = 0.002 and 0.001). Lower birth weight was associated with increased calculated insulin resistance (homeostasis model assessment [HOMA], P = 0.03), but was not related to the HOMA index of beta-cell function. The highest levels of IRS variables and total and LDL cholesterol were in children of low birth weight but high fat mass at 8 years. Taller height at 8 years predicted higher fasting plasma insulin concentrations, insulin resistance, and plasma total and LDL cholesterol concentrations. The most insulin-resistant children were those who had short parents but had themselves grown tall. Although the implications of our findings in relation to height are unclear, interventions to improve fetal growth and to control obesity in childhood are likely to be important factors in the prevention of cardiovascular disease and IRS in India.