Mitochondria-Associated Endoplasmic Reticulum Membranes in Cardiovascular Diseases.
Mitochondria-Associated Endoplasmic Reticulum Membranes in Cardiovascular Diseases.
复制标题
心血管疾病中的线粒体相关内质网膜。
DOI：
10.3389/fcell.2020.604240
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发表时间：
2020
影响因子：
5.5
通讯作者：
Zhu Z
中科院分区：
文献类型：
--
作者：
Gao P;Yan Z;Zhu Z
内质网(ER)和线粒体在物理上连接在一起，形成被称为线粒体相关ER膜(MAM)的特定结构域，参与基本的生物过程，包括脂质和钙(Ca~(2+))的动态平衡、线粒体动态以及其他相关的细胞行为，如自噬、内质网应激、炎症和细胞凋亡。大量研究证明，MAM在维持两种细胞器的正常功能中具有重要作用，MAM的数量、结构或功能异常与心血管疾病的发生有关。本文根据MAM的不同功能及其在心血管生理学和病理生理学中的具体作用，对MAM的组成进行综述，重点介绍一些常见的心血管疾病，包括缺血再灌注、糖尿病心肌病、心力衰竭、肺动脉高压和全身性血管疾病。最后，我们总结了MAM在心血管疾病中的可能机制，并提出了我们在理解MAM功能方面可能遇到的一些障碍。
The endoplasmic reticulum (ER) and mitochondria are physically connected to form dedicated structural domains known as mitochondria-associated ER membranes (MAMs), which participate in fundamental biological processes, including lipid and calcium (Ca2+) homeostasis, mitochondrial dynamics and other related cellular behaviors such as autophagy, ER stress, inflammation and apoptosis. Many studies have proved the importance of MAMs in maintaining the normal function of both organelles, and the abnormal amount, structure or function of MAMs is related to the occurrence of cardiovascular diseases. Here, we review the knowledge regarding the components of MAMs according to their different functions and the specific roles of MAMs in cardiovascular physiology and pathophysiology, focusing on some highly prevalent cardiovascular diseases, including ischemia-reperfusion, diabetic cardiomyopathy, heart failure, pulmonary arterial hypertension and systemic vascular diseases. Finally, we summarize the possible mechanisms of MAM in cardiovascular diseases and put forward some obstacles in the understanding of MAM function we may encounter.