Prevention of perinatal death and adverse perinatal outcome using low-dose aspirin: a meta-analysis
Prevention of perinatal death and adverse perinatal outcome using low-dose aspirin: a meta-analysis
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DOI：
10.1002/uog.12421
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发表时间：
2013-05-01
影响因子：
7.1
通讯作者：
Bujold, E.
中科院分区：
文献类型：
--
作者：
Roberge, S.;Nicolaides, K. H.;Bujold, E.
目的比较早期和晚期给药低剂量阿司匹林对围产儿死亡风险和不良围产儿结局的影响。方法在数据库中检索与阿司匹林与妊娠相关的关键词。仅纳入评估怀孕期间预防性使用低剂量阿司匹林（50- 150mg /天）的随机对照试验。主要结局包括胎儿和新生儿死亡。根据开始服用低剂量阿司匹林（妊娠16周）时的胎龄，对合并相对危险度（RR）和95% ci进行比较。结果在8377篇引用中，纳入42篇研究（27222名女性）。纳入标准是子痫前期的危险因素，包括：无产、多胎妊娠、慢性高血压、心血管或内分泌疾病、既往妊娠高血压或胎儿生长受限、和/或子宫动脉多普勒异常。与对照组相比，低剂量阿司匹林的起始剂量为
Objective To compare early vs late administration of low-dose aspirin on the risk of perinatal death and adverse perinatal outcome.Methods Databases were searched for keywords related to aspirin and pregnancy. Only randomized controlled trials that evaluated the prophylactic use of low-dose aspirin (50-150 mg/day) during pregnancy were included. The primary outcome combined fetal and neonatal death. Pooled relative risks (RR) with their 95% CIs were compared according to gestational age at initiation of low-dose aspirin ( 16 weeks of gestation).Results Out of 8377 citations, 42 studies (27 222 women) were included. Inclusion criteria were risk factors for pre-eclampsia, including: nulliparity, multiple pregnancy, chronic hypertension, cardiovascular or endocrine disease, prior gestational hypertension or fetal growth restriction, and/or abnormal uterine artery Doppler. When compared with controls, low-dose aspirin started at