Force-controlled ultrasound to measure passive mechanical properties of muscle in Duchenne muscular dystrophy.
Force-controlled ultrasound to measure passive mechanical properties of muscle in Duchenne muscular dystrophy.
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力控超声测量杜氏肌营养不良症患者肌肉的被动机械特性。
DOI：
10.1109/embc.2016.7591327
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Anthony,BrianW
中科院分区：
文献类型：
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作者：
Pigula,AnneJ;Wu,JimS;Gilbertson,MatthewW;Darras,BasilT;Rutkove,SewardB;Anthony,BrianW
本研究的目的是评估杜氏肌营养不良症（DMD）患者和正常人之间骨骼肌压缩性的差异。肌肉的横向被动力学特性，特别是与刚度和弹性相关的那些，可以使用力控超声来测量。我们采集了23名DMD男孩和20名年龄匹配的健康对照者在已知压力下二头肌和四头肌肌肉压缩的超声视频。我们计算了体积线性弹簧常数，非线性应力-应变响应，和平均杨氏模量为每个。发现DMD群体中二头肌（正常：33 ± 6 kPa，DMD：45 ± 14，p <0.01）和四头肌（正常：42 ± 6，DMD：58 ± 14，p <0.0001）的杨氏模量显著更高。通过力控超声测量肌肉可压缩性是一种客观和可靠的技术，可以定量监测DMD的影响并与正常受试者区分开来。
The purpose of this study is to assess differences in skeletal muscle compressibility between patients with Duchenne muscular dystrophy (DMD) and normal subjects. The transverse passive mechanical properties of muscle, particularly those related to stiffness and elasticity, can be measured using force-controlled ultrasound. We acquired ultrasound videos of muscle compression under known pressures in the biceps and quadriceps in 23 boys with DMD and 20 age-matched healthy controls. We calculated the bulk linear spring constant, nonlinear stress-strain response, and average Young's modulus for each. Young's modulus was found to be significantly higher in the DMD population in both the biceps (normal: 33 ± 6 kPa, DMD: 45 ± 14, p <; .01) and quadriceps (normal: 42 ± 6, DMD: 58 ± 14, p <; .0001). Muscle compressibility measured by force-controlled ultrasound is an objective and robust technique to quantitatively monitor the effects of DMD and distinguish from normal subjects.