Evolution of brain impedance in dystonic patients treated by GPi electrical stimulation
Evolution of brain impedance in dystonic patients treated by GPi electrical stimulation
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DOI：
10.1111/j.1094-7159.2004.04009.x
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发表时间：
2004-04-01
期刊：
影响因子：
2.8
通讯作者：
Coubes, P
中科院分区：
文献类型：
--
作者：
Hemm, S;Vayssiere, N;Coubes, P
脑深部电刺激是一种有效的治疗全身性肌张力障碍。最佳刺激参数因患者而异。本文研究了脑电阻抗和传递电流对大脑刺激反应的影响。24例患者通过两个植入的四触点电极在苍白球内侧进行双侧刺激。脑阻抗和电流测量的变化与刺激参数、时间过程和临床结果相关。当接触被激活时，发现脑阻抗的统计学显著和可逆的降低。阻抗和电流值及其随时间的变化在患者之间显著不同。绝对阻抗与最终结果无显著相关性。我们的结论是，可逆的阻抗下降反映了自适应的长期机制，这可能是由于可塑性现象，但没有预后价值。阻抗和电流测量为参数调整和故障排除提供了新的补充信息，因此应包括在所有患者的随访中。
Deep Brain Stimulation is an effective treatment of generalized dystonia. Optimal stimulation parameters vary between patients. This article investigates the influence of electrical brain impedance and delivered current on the brain response to stimulation. Twenty-four patients were bilaterally stimulated in the globus pallidus internus through two implanted four-contact electrodes. The variation of brain impedance and current measurements was correlated with stimulation parameters, time course, and clinical outcome. When a contact was activated, a statistically significant and reversible decrease of brain impedance was found. Impedance and current values and their variations with time significantly differed between patients. The absolute impedance did not significantly correlate with the final outcome. We conclude that the reversible decrease of impedance reflects an adaptive long-term mechanism, which could be due to a plasticity phenomenon, but has no prognostic value. Impedance and current measurements give new complementary information for parameter adjustment and trouble shooting and should therefore be included in all patients' follow-up.