Differential Accumulation and Elimination Behavior of Perfluoroalkyl Acid Isomers in Occupational Workers in a Manufactory in China
Differential Accumulation and Elimination Behavior of Perfluoroalkyl Acid Isomers in Occupational Workers in a Manufactory in China
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我国某工厂职业工人全氟烷基酸异构体的差异积累与消除行为
DOI：
10.1021/acs.est.5b00778
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发表时间：
2015-06-02
影响因子：
11.4
通讯作者：
Jiang, Guibin
中科院分区：
文献类型：
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作者：
Gao, Yan;Fu, Jianjie;Jiang, Guibin
本研究于2008年至2012年在中国某氟化工厂采集了36名职业工的血清和尿样，以评估其身体负荷以及直链和支链全氟烷基酸(PFAA)的消除情况。还收集了室内粉尘、总悬浮颗粒物(TSP)、饮食和饮用水样本，以追踪职业接触PFAA异构体的途径。血清中全氟辛烷磺酸(PFOS)、全氟辛酸(PFOA)和全氟己烷磺酸(PFHxS)异构体的几何平均浓度分别为1386、371和863 ng mL(-1)。全氟辛烷磺酸、全氟辛烷磺酸和全氟辛烷磺酸的线性异构体是血清中最主要的PFAA，其平均比例分别为63.3%、91.1%和92.7%，高于尿液中的比例。职业性接触PFAA异构体的最主要途径是室内粉尘和TSP的摄入量。肾脏清除量估算表明，支链PFAA异构体的肾脏清除率高于相应的线形异构体。分子对接模拟表明，线性全氟辛烷磺酸(n-全氟辛烷磺酸)与人血清白蛋白(HSA)的相互作用强于支链异构体，这可能通过转运人血清白蛋白来降低n-全氟辛烷磺酸在人体血液中的比例。
In this study, serum and urine samples were collected from 36 occupational workers in a fluorochemical manufacturing plant in China from 2008 to 2012 to evaluate the body burden and possible elimination of linear and branched perfluoroalkyl acids (PFAAs). Indoor dust, total suspended particles (TSP), diet, and drinking water samples were also collected to trace the occupational exposure pathway to PFAA isomers. The geometric mean concentrations of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS) isomers in the serum were 1386, 371, and 863 ng mL(-1), respectively. The linear isomer of PFOS, PFOA, and PFHxS was the most predominant PFAA in the serum, with mean proportions of 63.3, 91.1, and 92.7% respectively, which were higher than the proportions in urine. The most important exposure routes to PFAA isomers in the occupational workers were considered to be the intake of indoor dust and TSP. A renal clearance estimation indicated that branched PFAA isomers had a higher renal clearance rate than did the corresponding linear isomers. Molecular docking modeling implied that linear PFOS (n-PFOS) had a stronger interaction with human serum albumin (HSA) than branched isomers did, which could decrease the proportion of n-PFOS in the blood of humans via the transport of HSA.