Methotrexate hepatotoxicity in psoriasis. Consideration of liver biopsies at regular intervals.
Methotrexate hepatotoxicity in psoriasis. Consideration of liver biopsies at regular intervals.
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甲氨蝶呤在牛皮癣中的肝毒性。
DOI：
10.1001/archderm.1980.01640280049016
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发表时间：
1980
影响因子：
--
通讯作者：
R. Cimis
中科院分区：
文献类型：
--
作者：
J. K. Robinson;R. D. Baughman;R. Auerbach;R. Cimis
†在43名接受甲氨蝶呤维持治疗的银屑病患者中，有11名患者的肝纤维化发展到一定程度，禁止进一步使用甲氨蝶呤治疗。在开始甲氨蝶呤治疗前进行肝活检，每隔12至18个月重复一次。在这项回顾性研究中，发现患者年龄和治疗持续时间是仅接受每周口服给药方案的患者的重要因素。对于在整个治疗过程中接受甲氨蝶呤的患者，建议每年进行肝脏活检。（《皮肤病学文献》116：413-415，1980）
† Fibrosis of the liver developed to a degree that contraindicated further treatment with methotrexate in 11 of 43 patients who had been receiving maintenance therapy with methotrexate for psoriasis. Liver biopsy had been performed prior to initiation of methotrexate therapy and was repeated at 12- to 18-month intervals. In this retrospective study, age of the patient and duration of therapy have been found to be significant factors in those patients receiving only the weekly oral dosage schedule. Yearly biopsies of the liver are recommended for patients who receive methotrexate throughout their courses of therapy. ( Arch Dermatol 116:413-415, 1980)