Rechargeable microbial anti-adhesive polymethyl methacrylate incorporating silver sulfadiazine-loaded mesoporous silica nanocarriers
Rechargeable microbial anti-adhesive polymethyl methacrylate incorporating silver sulfadiazine-loaded mesoporous silica nanocarriers
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DOI：
10.1016/j.dental.2017.07.009
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发表时间：
2017-10-01
期刊：
影响因子：
5
通讯作者：
Lee, Hae-Hyoung
中科院分区：
文献类型：
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作者：
Jo, Jeong-Ki;El-Fiqi, Ahmed;Lee, Hae-Hyoung
目标.尽管聚甲基丙烯酸甲酯（PMMA）树脂被广泛用作牙科材料，但其抗微生物粘附性能较差，这会加速口腔感染。在这项调查中，银-磺胺嘧啶（AgSD）负载的介孔二氧化硅纳米粒子（AgMSNs）被纳入到PMMA中，以引入长期的微生物抗粘附作用，并使PMMA成为可充电树脂。在表征了Ag-MSNs的介孔特性和药物负载能力之后，在掺入Ag-MSNs（0.5%、1%、2.5%和5%）的PMMA中评价了3点弯曲试验和硬度。观察到抗粘附作用的白色念珠菌和口腔链球菌与实验标本长达28天，并与AgSD充电后。用于负载AgSD的MSN观察到典型的球形形态和高介孔性。将Ag-MSNs掺入PMMA（0.5%、1%、2.5%和5%）维持其弯曲强度，但增加其表面硬度。在暴露于两种微生物1小时后观察到抗粘附作用，并且该作用随着Ag-MSN掺入PMMA的增加而加速。长期的微生物抗粘连效果观察到长达14天，并进一步长期（7天）抗粘连效果后，观察到的Ag-MSN-合并的PMMA（老化28天）与AgSD重新加载;这些影响主要是由释放的银离子和部分由表面亲水性的变化。对角质形成细胞无细胞毒性。机械性能的改善和延长的微生物抗粘连效果，这持续后重新加载的药物，表明Ag-MSN-掺入的PMMA作为一种微生物抗粘连牙科材料的潜在用途。Ag-MSN-掺入的PMMA可用作义齿、正畸装置和临时修复材料的微生物防粘牙科材料。(C)2017年牙科材料学院。由爱思唯尔有限公司出版。保留所有权利。
Objectives. Even though polymethyl methacrylate (PMMA) resin is widely used as a dental material, it has poor microbial anti-adhesive properties, which accelerates oral infections. In this investigation, silver-sulfadiazine (AgSD)-loaded mesoporous silica nanoparticles (AgMSNs) were incorporated into PMMA to introduce long-term microbial anti-adhesive effects and to make PMMA a rechargeable resin.Methods. After characterization of the Ag-MSNs in terms of their mesoporous characteristics and drug loading capacity, the 3 point flexural test and hardness were evaluated in PMMA incorporating Ag-MSNs (0.5, 1,2.5 and 5%). Anti-adhesive effects were observed for Candida albicans and Streptococcus oralis with experimental specimens for up to 28 days and after recharging with AgSD.Results. A typical spherical morphology and high mesoporosity were observed for the MSNs used for loading AgSD. Incorporation of Ag-MSNs into PMMA (0.5, 1, 2.5 and 5%) sustained its flexural strength but increased its surface hardness. Anti-adhesive effects were observed after 1 h of exposure to both microbial species, and the effects accelerated with increasing Ag-MSN incorporation into PMMA. Long-term microbial anti-adhesive effects were observed for up to 14 days, and further long-term (7 days) anti-adhesive effects were observed after reloading the Ag-MSN-incorporated PMMA (aged for 28 days) with AgSD; these effects were largely caused by released silver ions and partially by changes in surface hydrophilicity. No cytotoxicity to keratinocytes was observed.Conclusions. The improved mechanical properties and the prolonged microbial anti-adhesive effects, which lasted after reloading of the drug, suggest the potential usefulness of Ag-MSN-incorporated PMMA as a microbial anti-adhesive dental material.Signcance. Ag-MSN-incorporated PMMA can be used as a microbial anti-adhesive dental material for dentures, orthodontic devices and provisional restorative materials. (C) 2017 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.