Association between multimorbidity and undiagnosed obstructive sleep apnea severity and their impact on quality of life in men over 40 years old.
Association between multimorbidity and undiagnosed obstructive sleep apnea severity and their impact on quality of life in men over 40 years old.
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DOI：
10.1017/gheg.2018.9
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Taylor AW
中科院分区：
文献类型：
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作者：
Ruel G;Martin SA;Lévesque JF;Wittert GA;Adams RJ;Appleton SL;Shi Z;Taylor AW
多发性睡眠呼吸暂停是常见的，但很少有人知道它与阻塞性睡眠呼吸暂停（OSA）的关系。男性雄激素炎症生活方式环境和压力研究参与者进行多导睡眠图。慢性疾病（CD）通过生物医学测量（糖尿病、血脂异常、高血压、肥胖）或自我报告（抑郁症、哮喘、心血管疾病、关节炎）确定。在校正年龄后，使用多项回归分析确定CD计数、多项睡眠呼吸暂停、呼吸暂停低通气指数（AHI）和OSA严重程度及生活质量（QoL;精神和身体成分评分）之间的相关性。在参与研究的743名男性中，58%患有多发性硬化症（2+ CD），52%患有OSA（11%严重）。大约70%的多发性硬化症患者患有未确诊的OSA。多发病与AHI和未确诊的OSA相关。CD计数升高与AHI值升高和OSA严重程度增加相关。我们证明了一个独立的协会之间的存在OSA和多发性硬化症在这个代表性样本的社区为基础的男子。这种效应在患有中度至重度OSA和三种或三种以上CD的男性中最强，并且当两种情况同时存在时，似乎会产生更大的QoL降低。
Multimorbidity is common but little is known about its relationship with obstructive sleep apnea (OSA). Men Androgen Inflammation Lifestyle Environment and Stress Study participants underwent polysomnography. Chronic diseases (CDs) were determined by biomedical measurement (diabetes, dyslipidaemia, hypertension, obesity), or self-report (depression, asthma, cardiovascular disease, arthritis). Associations between CD count, multimorbidity, apnea-hyponea index (AHI) and OSA severity and quality-of-life (QoL; mental & physical component scores), were determined using multinomial regression analyses, after adjustment for age. Of the 743 men participating in the study, overall 58% had multimorbidity (2+ CDs), and 52% had OSA (11% severe). About 70% of those with multimorbidity had undiagnosed OSA. Multimorbidity was associated with AHI and undiagnosed OSA. Elevated CD count was associated with higher AHI value and increased OSA severity. We demonstrate an independent association between the presence of OSA and multimorbidity in this representative sample of community-based men. This effect was strongest in men with moderate to severe OSA and three or more CDs, and appeared to produce a greater reduction in QoL when both conditions were present together.